Skip to main content
Log in

Evaluation of delayed puberty in the female adolescent with chronic renal failure

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

The purpose of this report is to discuss the differential diagnosis of delayed puberty in the adolescent female with chronic renal failure. The appropriate therapy varies depending on the etiology of the delay. Frasier syndrome — chronic renal failure with true gonadal dysgenesis — should be considered in the diagnosis of a normal phenotypic female with end-stage renal disease and delayed puberty.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bailey WA, Zwingman TA, Reznik VM, Griswold WR, Mendoza SA, Jones KL, Freidenberg GR (1992) Renal failure and primary hypogonadism associated with a 46 XX karyotype. Am J Dis Child 146:1218–1223

    Google Scholar 

  2. Frasier SD, Bashore RA, Mosier HD (1964) Gonadoblastoma associated with pure gonadal dysgenesis in monozygous twins. J Pediatr 64:740–745

    Google Scholar 

  3. Blanchet P, Daloze P, Lesage R, Papas S, Van Campenhout J (1977) XY gonadal dysgenesis with gonadoblastoma discovered after kidney transplantation. Am J Obstet Gynecol 129:221–222

    Google Scholar 

  4. Harkins PG, Haning RV, Shapiro SS (1980) Renal failure with XY gonadal dysgenesis: report of the second case. Obstet Gynecol 56: 751–752

    Google Scholar 

  5. Simpson JL, Changantl RSK, Mouradian J, German J (1982) Chronic renal disease, myotonic dystrophy, and gonadoblastoma in XY gonadal dysgenesis. J Med Genet 19:73–76

    Google Scholar 

  6. Haning RV, Chesney RW, Moorthy AV, Gilbert EF (1985) A syndrome of chronic renal failure and XY gonadal dysgenesis in young phenotypic females without genital ambiguity. Am J Kidney Dis 6: 40–48

    Google Scholar 

  7. Kinberg JA, Angle CR, Wilson RB (1987) Nephropathy-gonadal dysgenesis, type 2: renal failure in three siblings with XY dysgenesis in one. Am J Kidney Dis 9:507–510

    Google Scholar 

  8. Thomalla JV (1990) Chronic renal failure in an obese adolescent. Hosp Pract [Off] 25:128–133

    Google Scholar 

  9. Pallister PD, Opitz JM (1979) The Perreault syndrome: autosomal recessive ovarian dysgenesis with facultative, non-sex-limited sensorineural deafness. Am J Med Genet 4:239–246

    Google Scholar 

  10. Hamet P, Kuchel O, Nowacynski W, Rojo-Ortega JM, Sasaki C, Genest J (1973) Hypertension with adrenal, genital, renal defects and deafness. Arch Interm Med 131:563–569

    Google Scholar 

  11. Swyer G (1955) Male pseudohermaphroditism: a hereto undescribed form. BMJ 2:709–712

    Google Scholar 

  12. Damiani D, Billerbeck AE, Golberg AC, Setian N, Fellous M, Kalil J (1990) Investigation of the ZFY gene in XX true hermaphroditism and Swyer syndrome. Hum Genet 85:85–88

    Google Scholar 

  13. Oertel PJ, Lichtwald K, Häfner S, Rauh W, Schönberg D, Schärer (1983) Hypothalamo-pituitary-gonadal axis in children with chronic renal failure. Kidney Int 24:S34-S39

    Google Scholar 

  14. Gomez F, De la Cueva R, Wauters JP, Lemarchand-Beraud T (1980) Endocrine abnormalities in patients undergoing long-term hemodialysis. Am J Med 68:522–530

    Google Scholar 

  15. Handelsman DJ (1985) Hypothalamic-pituitary gonadal function in renal failure, dialysis and renal transplantation. Endocr Rev 6: 151–182

    Google Scholar 

  16. Scully RE (1970) Gonadoblastoma. A review of 74 cases. Cancer 25: 1340–1356

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reznik, V.M., Mendoza, S.A. & Freidenberg, G.R. Evaluation of delayed puberty in the female adolescent with chronic renal failure. Pediatr Nephrol 7, 551–553 (1993). https://doi.org/10.1007/BF00852544

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00852544

Key words

Navigation