Conclusions
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1.
The reaction of 6-methyluracil with dibutyl 4-chlorobutylphosphonate leads to the formation of 1,3-bis-[4′-dibutylphosphono)butyl]-6-methyluracil.
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2.
The reaction of 2-amino-4-hydroxy-6-methylpyrimidine with dibutyl 4-chlorobutylphosphonate leads to the formation of a mixture of 2-amino-4-[4′-(dibutylphosphono)butyl]oxy-6-methylpyrimidine and the dibutyl ester of 4′-(2-amino-4-oxo-6-methyl-3,4-dihydro-3-pyrimidinyl)-butylphosphonic acid.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 10, pp. 2231–2237, October, 1971.
The authors wish to thank N. V. Teptin, A. V. Chernov and G. M. Dorozhkin for assistance in taking the IR and UV spectra.
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Reznik, V.S., Shvetsov, Y.S. Synthesis and properties of pyrimidinylalkylphosphonic acids. Russ Chem Bull 20, 2108–2113 (1971). https://doi.org/10.1007/BF00851260
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DOI: https://doi.org/10.1007/BF00851260