Pediatric Nephrology

, Volume 3, Issue 4, pp 386–390 | Cite as

P-fimbriae vaccines

I. Cross reactive antibodies to heterologous P-fimbriae
  • M. Bernice Kaack
  • Auli Pere
  • Timo K. Korhonen
  • Stefan B. Svenson
  • James A. Roberts
Original Article


To test for cross-protective capacity of two different P-fimbriae vaccines we vaccinated baboons with fimbriae purified from eitherEscherichia coli strain ER2 or strain JR1. The vaccinated animals showed elevated antibody titers to P-fimbriae from each of theE. coli strains used, suggesting cross-reactivity as was expected from the results of immunoprecipitation of the fimbriae. Enzyme-linked immunosorbent assay inhibition by heterologous P-fimbriae proved this to be true immunologic cross-reactivity.

Key words

P-fimbriae Vaccines Antibodies, cross-reactive Escherichia coli 


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Copyright information

© IPNA 1989

Authors and Affiliations

  • M. Bernice Kaack
    • 1
    • 2
    • 4
  • Auli Pere
    • 3
    • 4
  • Timo K. Korhonen
    • 3
    • 4
  • Stefan B. Svenson
    • 1
    • 4
  • James A. Roberts
    • 1
    • 2
    • 4
  1. 1.Department of UrologyDelta Regional Primate Research CenterCovingtonUSA
  2. 2.Department of UrologyTulane Medical SchoolNew OrleansUSA
  3. 3.Department of General MicrobiologyUniversity of HelsinkiHelsinkiFinland
  4. 4.Department of MicrobiologyThe National Bacteriological LaboratoryStockholmSweden

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