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Synthesis of cytosine derivatives from 1-substituted uracils

  • S. I. Zav'yalov
  • V. I. Gunar
  • Z. A. Martirosyan
  • L. F. Ovechkina
Organic and Biological Chemistry

Conclusions

  1. 1.

    A mixture of the O2-, N3-, and O4-alkylation products is formed when the Ag salt of 1-phenyl-6-methyluracil is reacted with isopropyl iodide in either n-octane or an alcohol medium.

     
  2. 2.

    The Na salt of 2-methylthio-4-hydroxy-6-methylpyrimidine undergoes selective O-alkylation by the bimolecular mechanism when it is reacted with isopropyl iodide in dimethylformamide.

     
  3. 3.

    The 04-isopropyl derivatives of N′-substituted uracils enter into the amination reaction under the influence of primary amines and hydrazine hydrate to give the corresponding substituted cytosines.

     
  4. 4.

    1-Phenyl-6-methyluracil is cleaved to N,N′-dibenzylurea when heated with benzylamine.

     

Keywords

Hydrate Hydrazine Cytosine Isopropyl Uracil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1973

Authors and Affiliations

  • S. I. Zav'yalov
    • 1
  • V. I. Gunar
    • 1
  • Z. A. Martirosyan
    • 1
  • L. F. Ovechkina
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRUSSR

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