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Asymmetric reduction of phenylα- andβ-dialkylamino ketones by treatment with optically active organomagnesium compounds

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    Whenα-dimethylaminoacetophenone andβ-dimethylaminopropiophenone are reduced by optically active organomagnesium compounds the asymmetric reduction proceeds with an optical yield of 65–70%.

  2. 2.

    The absolute configuration for the obtained amino alcohols was proposed on the basis of the optical rotation dispersion data.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, USSR

    L. D. Tomina, E. I. Klabunovskii, Yu. I. Petrov, E. D. Lubuzh & E. M. Cherkasova

  2. The M. V. Lomonosov Institute of Fine Chemical Technology, USSR

    L. D. Tomina, E. I. Klabunovskii, Yu. I. Petrov, E. D. Lubuzh & E. M. Cherkasova

Authors
  1. L. D. Tomina
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  2. E. I. Klabunovskii
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  3. Yu. I. Petrov
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  4. E. D. Lubuzh
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  5. E. M. Cherkasova
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2506–2510, November, 1972.

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Tomina, L.D., Klabunovskii, E.I., Petrov, Y.I. et al. Asymmetric reduction of phenylα- andβ-dialkylamino ketones by treatment with optically active organomagnesium compounds. Russ Chem Bull 21, 2437–2440 (1972). https://doi.org/10.1007/BF00850088

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  • DOI: https://doi.org/10.1007/BF00850088

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