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Dispersion of the optical rotation and circular dichroism in structural and stereochemical problems

Communication 2. The manifestation of chiral-optic effects in steroids of the pregnane series containing sulfur at C17

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The chiral-optic properties of 17-sulfur-containing steroids of the pregnane series were investigated in the region of the p→π* transition of the 20-C=O and thiolacetate groups and the p→σ *5 transition of the C-S-C chromophore.

  2. 2.

    A 17α-substituent containing sulfur inverts the sign of the Cotton effect of the corresponding derivatives of Δ5-pregnene-3β-ol-20-one.

  3. 3.

    Considerations were expressed on the influence of substitution at C17 on the nature of the circular dichroism curves in the steroid series studied.

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Literature cited

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, USSR

    A. A. Akhrem, G. A. Kogan, A. M. Turuta, I. S. Kovnatskaya & Z. I. Istomina

  2. M. M. Shemyakin Institute of the Chemistry of Natural Compounds, Academy of Sciences of the USSR, USSR

    A. A. Akhrem, G. A. Kogan, A. M. Turuta, I. S. Kovnatskaya & Z. I. Istomina

Authors
  1. A. A. Akhrem
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  2. G. A. Kogan
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  3. A. M. Turuta
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  4. I. S. Kovnatskaya
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  5. Z. I. Istomina
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Additional information

For Communication 1, see [1].

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2688–2693, December, 1972.

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Akhrem, A.A., Kogan, G.A., Turuta, A.M. et al. Dispersion of the optical rotation and circular dichroism in structural and stereochemical problems. Russ Chem Bull 21, 2620–2624 (1972). https://doi.org/10.1007/BF00849825

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  • DOI: https://doi.org/10.1007/BF00849825

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