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β-Dicarbonyl compounds Communication 22. Synthesis and fungistatic activity of some simple analogs of the antibiotic griseofulvin

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Summary

  1. 1.

    Enol ethers of 1,3-cyclohexanedione derivatives and 7,8-dihydro-5(6H)-chromanone derivatives were synthesized and tested for fungistatic activity. The compound of highest antifungal activity was 7,8-dihydro-2-methyl-2-(4-methyl-3-pentenyl)-5(6H)-chromanone (IX).

  2. 2.

    A new method was developed for the synthesis of 7,8-dihydro-5(6H)-chromanone derivatives by the reaction of 1,3-cyclohexanedione with Mannich ketones and the subsequent reduction and cyclization of the condensation products.

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Literature cited

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences, USSR

    V. I. Gunar, L. F. Ovechkina, S. I. Zav'yalov, G. N. Pershin & S. N. Milovanova

  2. S. Ordzhonikidze All-Union Chemical and Pharmaceutical Research Institute, USSR

    V. I. Gunar, L. F. Ovechkina, S. I. Zav'yalov, G. N. Pershin & S. N. Milovanova

Authors
  1. V. I. Gunar
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  2. L. F. Ovechkina
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  3. S. I. Zav'yalov
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  4. G. N. Pershin
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  5. S. N. Milovanova
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seria Khimicheskaya, No. 10, pp. 1827–1831, October, 1964

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Gunar, V.I., Ovechkina, L.F., Zav'yalov, S.I. et al. β-Dicarbonyl compounds Communication 22. Synthesis and fungistatic activity of some simple analogs of the antibiotic griseofulvin. Russ Chem Bull 13, 1731–1734 (1964). https://doi.org/10.1007/BF00849437

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  • DOI: https://doi.org/10.1007/BF00849437

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