Conclusions
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1.
The limiting step in the inactivation of lactate dehydrogenase by the oxidized inhibitor is the step of formation of a semiquinone radical of the inhibitor.
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2.
The protective action of nicotinamide-adenine-dinucelotide against the inactivation of lactate dehydrogenase was demonstrated, and the possible mechanism of this phenomenon was considered.
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The article is published on the basis of a resolution of the Conference of Editors-in-Chief of the Journals of the Academy of Sciences, USSR, of July 12, 1962, as the dissertation work of L. S. Vartanyan.
Translated from Izvestiya Akademii Nauk SSSR, Seria Khimicheskaya, No. 10, pp. 1742–1748, October, 1964
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Vartanyan, L.S., Gonikberg, É.M. & Émanuél, N.M. Kinetics of the inactivation of lactate dehydrogenase by radical products of the autooxidation of propyl gallate. Russ Chem Bull 13, 1656–1660 (1964). https://doi.org/10.1007/BF00849424
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DOI: https://doi.org/10.1007/BF00849424