Pediatric Nephrology

, Volume 1, Issue 3, pp 385–392

Early organogenesis of the kidney

  • Lauri Saxén
  • Hannu Sariola
International Symposium on Hereditary Nephropathies Heidelberg, 6–8 October, 1986

DOI: 10.1007/BF00849241

Cite this article as:
Saxén, L. & Sariola, H. Pediatr Nephrol (1987) 1: 385. doi:10.1007/BF00849241


The mammalian permanent kidney consists of three cell lineages of different origin: the epithelial cells of the ureter bud, the mesenchymal cells of the nephric blastema and the endothelial cells of the capillaries. Organogenesis is governed by a cascade of morphogenetic interactions between these cell populations, a reciprocal epithelial-mesenchymal interaction between the branching ureter and the metanephric mesenchyme, homotypic interactions between cells of the tubular anlagen, stimulation of angiogenesis by the differentiating blastema and a mesenchymal-endothelial interaction guiding the migration of the capillary endothelial cells. While the biology of these interactive events is well known, as described in this overview, the molecular mechanisms are less well mapped out.

Key words

Kidney organogenesis Inductive tissue interactions Metanephric mesenchyme Angiogenesis 

Copyright information

© IPNA 1987

Authors and Affiliations

  • Lauri Saxén
    • 1
  • Hannu Sariola
    • 1
  1. 1.Department of PathologyUniversity of HelsinkiHelsinkiFinland

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