Summary
A reversible inhibitor of ribonucleic acid synthesis, 2-mercapto-1-(β-4-pyridethyl) benzimidazole (MPB), provoked vegetalization of sea urchin larvae. Some structural analogues of MPB showed no vegetalizing effect. Two other inhibitors of ribonucleic acid synthesis, Cordycepin and 5,6-dichloro-(β-D-ribofuranosyl) benzimidazole, did not exert vegetalizing effects. MPB inhibited oxygen consumption. This inhibitor diminished the rate of incorporation of uridine and valine into acid-insoluble material. The mode of action of MPB is discussed. It is suggested that this agent exerts a control at post-transcriptional levels.
Résumé
Les œufs de l'OursinParacentrotus lividus traités par un inhibiteur réversible des synthèses d'acides ribonucléiques, le 2, mercapto-1-(β-4-pyridéthyl) benzimidazole (MPB) forment des larves typiquement végétalisées. Des analogues structuraux de MPB étudiés dans ce travail ne montrent aucun effet végétalisant. Deux autres inhibiteurs des synthèses d'acides ribonucléiques, la cordycépine et le 5,6-dichloro (β-D-ribofuranosyl) benzimidazole n'exercent pas d'effets végétalisants. MPB inhibe la consommation d'oxygène. Cet agent diminue le taux d'incorporation de l'uridine et de la leucine dans le matériel acido-insoluble. Le mode d'action du MPB est discuté. Un contrôle exercé par cet agent à un niveau post-transcriptionnel est suggéré.
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Lallier, R. Effets du 2-mercapto-1-(β-4-pyridéthyl) benzimidazole sur le développement et le métabolisme de l'œuf de l'OursinParacentrotus lividus . Wilhelm Roux' Archiv 182, 293–304 (1977). https://doi.org/10.1007/BF00848381
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DOI: https://doi.org/10.1007/BF00848381