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Mutations of early neurogenesis inDrosophila

  • Ruth Lehmann
  • Ursula Dietrich
  • F. Jiménez
  • J. A. Campos-Ortega
Rapid Communication

Summary

Embryonic lethal mutations at the Notch locus are known to produce a conspicuous central nervous system hypertrophy accompanied by a hypotrophy of the epidermal sheath. We have studied several zygotic mutants belonging to four different autosomal complementation groups which produce the same phenotype. The embryonic development of the new mutants, as well as that of Notch, consists of an initial enlargement of the neurogenic region at the expenses of epidermal cell precursors. The possibility is discussed that these five loci are involved in the determination of neural and epidermal cell precursors.

Key words

Early neurogenesis Mutants Drosophila melanogaster 

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References

  1. Ashburner M, Richards G, Velissariou V (1980) Report on new mutants. DIS 55:196Google Scholar
  2. Bauer V (1904) Zur inneren Metamorphose des Zentralnervensystems der Insekten. Zool Jahrb Abt Anat Ontog Tiere 20:123–150Google Scholar
  3. Bridges CB, Morgan TH (1923) Publ. No. 327 Carnegie Institute Washington (Quoted in Lindsley and Grell 1968)Google Scholar
  4. Campos-Ortega JA, Jiménez F (1980) The effect of X-chromosome deficiencies on neurogenesis inDrosophila In: Siddiqi O, Babu P, Hall LM, Hall JC (eds) Development and neurobiology ofDrosophila. Plenum Press, New York, pp 201–222Google Scholar
  5. Jiménez F, Campos-Ortega JA (1979) A region of theDrosophila genome necessary for CNS development. Nature 282:310–312Google Scholar
  6. Johnson CD, Russell RL (1975) A rapid simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal Biochem 64:229–238Google Scholar
  7. Lindsley DL, Grell EH (1968) Genetic variations ofDrosophila melanogaster. Carnegie Institute Publ., WashingtonGoogle Scholar
  8. Meer J Van der (1977) Optical clean and permanent wholemount preparation for phase-contrast microscopy of cuticular structures of insect larvae. DIS 52:160Google Scholar
  9. Mohr OL (1919) Character changes caused by mutation of an entire region of a chromosome inDrosophila. Genetics 4:275–282Google Scholar
  10. Nüsslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity inDrosophila. Nature 287:795–801Google Scholar
  11. Poulson DF (1937) Chromosomal deficiencies and the embryonic development ofDrosophila melanogaster. PNAS 23:133–137Google Scholar
  12. Poulson DF (1940) The effect of certain X-chromosome deficiencies on the embryonic development ofDrosophila melanogaster. J Exp Zool 83:271–325Google Scholar
  13. Poulson DF (1945) Chromosomal control of embryogenesis inDrosophila. Am Nat 79:340–363Google Scholar
  14. Poulson DF (1950) Histogenesis, organogenesis and differentiation in the embryo ofDrosophila melanogaster Meigen. In: Demerec M (ed) Biology ofDrosophila. Wiley, New York, pp 168–274Google Scholar
  15. Poulson DF (1968) The embryogenetic function of the Notch locus inDrosophila melanogaster. Proc. 12th Int Congr Genetics Tokyo 1:143Google Scholar
  16. Schoeller J (1964) Recherches descriptives et expérimentales surgy céphalogenèse deCalliphora erytrocephala (Meigen), au cours du développement embryonnaire et postembryonaire. Arch Zool Exp Gen 103:1–216Google Scholar
  17. Seattle-La Jolla Drosophila Laboratories (1971) The use of Y-autosome translocations in the construction of autosomal deficiencies and duplications. DIS 47: SupplGoogle Scholar
  18. Turner RF, Mahowald AP (1979) Scanning electron microscopy ofDrosophila melanogaster embryogenesis. III Formation of the head and caudal segments. Dev Biol 68:96–109Google Scholar
  19. Wheeler WM (1891) neuroblasts in the arthroped embryo. J Morphol 4:337–344Google Scholar
  20. Wright TRF (1970) The genetics of embryogenesis inDrosophila. Adv Genet 15:261Google Scholar
  21. Zalokar M, Erk I (1977) Phase-partition fixation and staining ofDrosophila eggs. Stain Technol 52:89–95Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Ruth Lehmann
    • 1
  • Ursula Dietrich
    • 1
  • F. Jiménez
    • 1
  • J. A. Campos-Ortega
    • 1
  1. 1.Institut für Biologie IIIFreiburg i. Br.Germany

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