Über die Anwendung von Nicotinsäureamid beim histochemischen Nachweis pyridinnucleotidgebundener Enzyme im Hirngewebe

  • H. Nasu
  • G. L. Viale
Article

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Alivisatos, S. G. A., andO. F. Denstedt: Lactic dehydrogenase and DPN-ase activity of blood. Science114, 281–283 (1951).PubMedGoogle Scholar
  2. —— Nicotinamide inhibition of tri- and di-phosphopyridine nucleotide-linked dehydrogenases. J. biol. Chem.199, 493–504 (1952).PubMedGoogle Scholar
  3. Chason, J. L., andA. G. E. Pearse: Phenazine methosulphate and nicotinamide in the histochemical demonstration of dehydrogenases in rat brain. J. Neurochem.6, 259–266 (1961).PubMedGoogle Scholar
  4. Ernster, L., andF. Navazio: Studies on TPN-linked oxidations. I. Pathways of isocitrate oxidation in rat liver mitochondria. Biochem. biophys. Acta26, 408–415 (1957).PubMedGoogle Scholar
  5. Farber, E., W. H. Sternberg andC. E. Dunlap: Tetrazolium stains for diphosphopyridine nucleotide (DPN) diaphorase and triphosphopyridine nucleotide (TPN) diaphorase in animal tissue. Proc. Soc. exp. Biol. (N.Y.)86, 534–537 (1954).Google Scholar
  6. —— —— —— Histochemical localization of specific oxidative enzymes. I. Tetrazolium stains for diphosphopyridine nucleotide diaphorase and triphosphopyridine nucleotide diaphorase. J. Histochem. Cytochem.4, 254–265 (1956a).PubMedGoogle Scholar
  7. —— —— —— Histochemical localization of specific oxidative enzymes. III. Evaluation studies of tetrazolium staining method for diphosphopyridine nucleotide diaphorase, triphosphopyridine nucleotide diaphorase and the succindehydrogenase system. J. Histochem. Cytochem.4, 284–294 (1956b).PubMedGoogle Scholar
  8. Feigelson, P., J. N. Williams andC. A. Elvehjem: Inhibition of diphosphopyridine nucleotide-requiring enzymes by nicotinamide. J. biol. Chem.189, 361–369 (1951).PubMedGoogle Scholar
  9. Gore, M., F. Libott andMcIlwain: The cozymase of mammalian brain. Biochem. J.47, 121–127 (1950).Google Scholar
  10. Handler, P., andJ. R. Klein: The inactivation of pyridine nucleotides by animal tissues in vitro. J. biol. Chem.143, 49–57 (1942).Google Scholar
  11. Holzer, H., u.S. Schneider: Wasserstoffübertragung von TPNH auf DPN unter Vermittlung von Glutaminsäure-dehydrogenase und Milchsäure-dehydrogenase. Biochem. Z.330, 240–244 (1958).PubMedGoogle Scholar
  12. Kornberg, A., andO. Lindberg: Diphosphopyridine nucleotide pyrophosphatase. J. biol. Chem.176, 665–677 (1948).Google Scholar
  13. McIlwain, H.: Cozymase degradation and the control of carbohydrate metabolism in brain. Biochem. J.44, XXXIII-XXXIV (1949).Google Scholar
  14. —— Properties of preparations from the central nervous system which degrade coenzyme I and II; their connexion with carbohydrate metabolism. Biochem. J.45, 612–619 (1950).Google Scholar
  15. —— Biochemistry and the central nervous system. London: Churchill 1955.Google Scholar
  16. ——, andR. Rodnight: Breakdown of cozymase by a system from nervous tissue. Biochem. J.44, 470–477 (1949).Google Scholar
  17. Mann, P. J. G., andJ. H. Quastel: Nicotinamide, cozymase and tissue metabolism. Biochem. J.35, 502–517 (1941).Google Scholar
  18. Pearse, A. G. E.: Histochemistry, theoretical and applied. London: Churchill 1960.Google Scholar
  19. Potanos, J. N., A. Wolf andD. Cowen: Cytochemical localization of oxidative enzymes in the human central and peripheral nervous systems. J. Neuropath.19, 143–144 (1960).Google Scholar
  20. Romanul, F. C. A., andR. B. Cohen: A histochemical study of dehydrogenases in the central and peripheral nervous systems. J. Neuropath. exp. Neurol.19, 135–136 (1960).Google Scholar
  21. Stein, A. M., andN. O. Kaplan: The diaphorase of rat liver mitochondria. Biochim. biophys. Acta29, 452–453 (1958).PubMedGoogle Scholar
  22. Weber, M. M., andN. O. Kaplan: Flavoprotein-catalyzed pyridine nucleotide transfer reactions. J. biol. Chem.225, 909–920 (1957).PubMedGoogle Scholar
  23. Wolfgram, F., andA. S. Rose: The histochemical demonstration of dehydrogenases in neuroglia. Exp. Cell Res.17, 526–530 (1959).PubMedGoogle Scholar
  24. Zimmermann, H., andA. G. E. Pearse: Limitation in the histochemical demonstration of pyridine nucleotide-linked dehydrogenases („nothing dehydrogenase“). J. Histochem. Cytochem.7, 271–275 (1959).PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1961

Authors and Affiliations

  • H. Nasu
    • 1
  • G. L. Viale
    • 1
  1. 1.Abteilung für Tumorforschung und experimentelle Pathologie, und der Neurochirurgischen Universitätsklinik KölnAus dem Max Planck-Institut für HirnforschungGermany

Personalised recommendations