Mannich reaction in the series of 4-hydroxy-3,5-dialkylacetophenones

  • A. A. Volod'kin
  • V. V. Ershov
  • N. V. Portnykh
Brief Communications


A study was made of the aminomethylation of some 4-hydroxy-3,5-dialkylacetophenones under the conditions of the Mannich reaction. The character of the secondary amine and the degree of steric hindrance of the phenolic hydroxy are essentially without effect on the yields of the 4-hydroxy-3,5-dialkyl-β-(N,N-dialkylamino)-propiophenones.


Steric Hindrance Secondary Amine Mannich Reaction Phenolic Hydroxy Propiophenones 
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Copyright information

© Consultants Bureau 1967

Authors and Affiliations

  • A. A. Volod'kin
    • 1
    • 2
  • V. V. Ershov
    • 1
    • 2
  • N. V. Portnykh
    • 1
    • 2
  1. 1.Institute of Chemical PhysicsAcademy of Sciences of the USSRUSSR
  2. 2.Moscow Cooperative InstituteUSSR

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