Summary
An investigation was carried out on immune sera obtained from 19 rabbit-recipients of skin homotransplants. The reaction of hemagglutination of these sera with erythrocytes of a large number (60) of rabbits was tested. On the grounds of the similarity of behavior of erythrocytes towards the immune sera, and of the immune sera with respect to the erythrocytes, the rabbits could be subdivided into several groups. However, there were antigenic differences between the rabbits even within a group. The antigenic similarities and differences of the rabbits were confirmed by the reaction of adsorption of the sera by the erythrocytes. The data obtained in these experiments make it possible to assume that the humoral changes produced as a result of skin transplantation are of the specific immune iso-antibody nature.
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Zotikov, E.A. The specificity of the humoral factors in transplantational immunity. Bull Exp Biol Med 46, 1357–1361 (1958). https://doi.org/10.1007/BF00845181
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DOI: https://doi.org/10.1007/BF00845181