The competition of allergic processes

Summary

This work was conducted on guinea pigs sensitized by various doses of horse and ox sera simultaneously or at various intervals between the administration of the allergens (on the 3rd, 7th, 14th and 21st day). The allergic reorganization was judged by the death of the animals in injecting the booster dose of one of the allergens, the value of the antibodies—precipitins for them, as well as the reaction of the isolated intestinal portion to the allergens. It was demonstrated that at the peak of the allergic reorganization (in 7–14 days) the body is relatively refractory to the sensitization by other allergens, which is demonstrated by the survival of more than 50% of the animals injected with a booster dose (with the 100% mortality rate of the control animals), by the considerable depression in the production of precipitins, and decreased reaction of the smooth muscles to the second allergen.