Summary
It was demonstrated in this work that the complete isolation of the carotid sinus from the blood and the lymph circulation excludes the possibility of the reflex production of antibodies when the antigen acts on the glomus chemoreceptors alone. It was established by investigation of antigen resorption from the isolated carotid sinus by the leakage determination method that on the average about 24% of the antigen injected into the sinus is resorbed within the first 5 minutes. The determination of the antigen content in the sinocarotid nerve under these conditions demonstrated that one of the important paths of resorption was the perineural lymphatic spaces, and possibly the blood capillaries.
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Ado, A.D., Ishimova, L.M. Concerning the reflex mechanism of antibody formation. Bull Exp Biol Med 46, 1305–1310 (1958). https://doi.org/10.1007/BF00845170
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DOI: https://doi.org/10.1007/BF00845170