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The combined activity of the spleen and other organs

Communication I. The effect of experimental splenopathy on the functional state of the thyroid gland and ovaries

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

The author studied the effect of experimental splenomegaly (caused by the intraperitoneal injection of methyl cellulose to white rats) on the functional state of the thyroid gland (by the absorption of I131 by the gland) and of the ovaries (by studying the estrus cycle). It was established that splenopathy brought about pronounced depression of the functional activity of the thyroid gland and the ovaries. This phenomenon is caused by splenomegaly since the administration of methyl cellulose to splenectomized animals does not cause such changes in the thyroid gland and the ovaries. It was demonstrated that the changes in the estral cycle in splenopathy did not depend on disturbance of the gonadotropic activity of the hypophysis or on changes in the sensitivity of the vaginal mucosa to the estrogenic action.

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Authors and Affiliations

  1. The Ufa Scientific-Research Institute of Hygiene and Industrial Diseases, Ufa, USSR

    L. J. Geller

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  1. L. J. Geller
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Geller, L.J. The combined activity of the spleen and other organs. Bull Exp Biol Med 46, 1300–1304 (1958). https://doi.org/10.1007/BF00845169

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  • DOI: https://doi.org/10.1007/BF00845169

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