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Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 3, pp 1171–1173 | Cite as

Effect of imipramine-like antidepressants on head twitching in mice induced by 5-hydroxytryptophan

  • E. L. Shelkunov
Pharmacology

Abstract

When headtwitching (HT) in mice in response to administration of 5-hydroxytryptophan (5-HTP) was used as a “serotoninergic” model the antidepressants chlorimipramine and imipramine, and also chlorpheniramine (suprastin), exhibited a serotonin-positive action in doses of 1.0, 5.0, and 1.0 mg/kg respectively. Quipazine had a serotoninomimetic action, desipramine an ambivalent action in doses of 1–20 mg/kg, whereas iprindole and morphaphen were ineffective in doses of up to 20 mg/kg. Amitryptiline, noveril (dibenzepine), melitracene, trimeprimine (trimipramine), and ludiomil (maprotiline) exhibited an antiserotonin action in doses of 0.5, 1.0, 20.0, and 20.0 mg/kg respectively. The results are discussed in the light of the concept of a complex spectrum of mediator activity of the imipramine-like antidepressant.

Key Words

antidepressants anti- and proserotonin action screening 5-hydroxytryptophan head twitching 

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • E. L. Shelkunov

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