Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 3, pp 1168–1170 | Cite as

Effect of benactyzine and arecoline on the45Ca uptake by rat brain nerve endings

  • E. V. Semenov
Pharmacology
  • 16 Downloads

Abstract

The effect of the central cholinolytic benactyzine and the cholinomimetic arecoline on the uptake of45Ca by rat brain synaptosomes was studied in vitro. Benactyzine was shown to cause biphasic changes (a decrease followed by an increase) in the intensity of uptake of the isotope, whereas arecoline led to a rapid initial increase in45Ca uptake. Benactyzine was shown to depress the effect of arecoline and depolarization on uptake of the isotope. It is concluded that the increase in45Ca uptake through the action of arecoline is connected with activation of Nachannels. Benactyzine, on the other hand, reduces the permeability of the these channels for45Ca and activates the Ca-channels proper.

Key words

synaptosomes benactyzine arecoline depolarization 45Ca uptake 

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • E. V. Semenov

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