Bulletin of Experimental Biology and Medicine

, Volume 86, Issue 3, pp 1168–1170 | Cite as

Effect of benactyzine and arecoline on the45Ca uptake by rat brain nerve endings

  • E. V. Semenov


The effect of the central cholinolytic benactyzine and the cholinomimetic arecoline on the uptake of45Ca by rat brain synaptosomes was studied in vitro. Benactyzine was shown to cause biphasic changes (a decrease followed by an increase) in the intensity of uptake of the isotope, whereas arecoline led to a rapid initial increase in45Ca uptake. Benactyzine was shown to depress the effect of arecoline and depolarization on uptake of the isotope. It is concluded that the increase in45Ca uptake through the action of arecoline is connected with activation of Nachannels. Benactyzine, on the other hand, reduces the permeability of the these channels for45Ca and activates the Ca-channels proper.

Key words

synaptosomes benactyzine arecoline depolarization 45Ca uptake 


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Literature Cited

  1. 1.
    A. L. Bandman, L. V. Smirnova, and G. A. Sofronov, Byull. Éksp. Biol. Med., No. 7, 56 (1973).Google Scholar
  2. 2.
    I. I. Baryshnikov, Tr. Voen.-Med. Akad.,190, 138 (1970).Google Scholar
  3. 3.
    N. R. Elaev, M. O. Karryeva, and M. P. Podosinovikova, Farmakol. Tolsikol., No. 5, 632 (1972).Google Scholar
  4. 4.
    S. S. Krylov and E. A. Snegirev, Byull. Éksp. Biol. Med., No. 9, 49 (1970).Google Scholar
  5. 5.
    V. F. Shirokii, The Problem of Quality of Chemical Stimulation [in Russian], Volgograd (1950).Google Scholar
  6. 6.
    L. G. Abood, in: Psychotomimetic Drugs (ed. by D. H. Efron), New York (1970), p. 67.Google Scholar
  7. 7.
    P. E. Baker, A. L. Hodgkin, and E. B. Ridgway, J. Physiol. (London),218, 709 (1971).Google Scholar
  8. 8.
    T. Godfraind, in: Pharmacology and the Future of Man (International Congress), Vol. 4, Basel (1973), p. 344.Google Scholar
  9. 9.
    B. Katz and R. Miledi, J. Physiol. (London),203, 459 (1969).Google Scholar
  10. 10.
    W. Van der Kloot and H. Kita, J. Membrane Biol.,14, 365 (1973).Google Scholar
  11. 11.
    O. H. Lowry, N. J. Rosebrough, A. L. Farr, et al., J. Biol. Chem.,193, 265 (1951).Google Scholar
  12. 12.
    E. Matthews and J. Nordmann, Molec. Pharmacol.,12, 778 (1976).Google Scholar
  13. 13.
    E. Muscholl, H. Ritzel, and K. Rossler, Brit. J. Pharmacol.,55, 248 (1975).Google Scholar
  14. 14.
    H. Tischer and W. Oelssner, Acta Biol. Med. Germ.,18, 443 (1967).Google Scholar
  15. 15.
    W. Whittaker, Prog. Biophys. Molec. Biol.,15, 39 (1965).Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • E. V. Semenov

There are no affiliations available

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