Deformation of the transpulmonary pressure plateau in experimental emphysema
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Deformation of the transpulmonary pressure plateau obtained during interruption of the air flow for 0.5 sec in 8 healthy rabbits and in 9 rabbits with experimental emphysema caused by intravenous injection of lycopodium spores is described. Greatest deformation of the plateau was observed in healthy animals at inspiration (on average up to 20 mm water). In rabbits with emphysema the degree of deformation was reduced on average to 13 cm water. At expiration deformation of the plateau was equal in the healthy and emphysematous rabbits, with a mean value of about 7 cm water. The direction of the change in the effect of the respiratory muscles at inspiration or expiration during interruption of the air flow was monitored by recording the pressure in the bronchus, in which the amplitude of the respiratory fluctuations considerably exceeded that of the transpulmonary pressure. Deformation of the plateau at inspiration is regarded as the result of the active sucking action of the lungs, and at expiration, as their active contraction during interruption of the air flow.
Key Wordstranspulmonary pressure emphysema of the lungs
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