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Aminotriazoles in the Mannich reaction

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Summary

  1. 1.

    By the condensation of esters of glycolic, lactic, and hydracrylic acids with hydrazine hydrate, 3,5-di-(hydroxyalkyl)-4-amino-1, 2,4-triazoles have been obtained for the first time and characterized.

  2. 2.

    3,5-Di-(hydroxyalkyl)-4-amino-1,2,4-triazoles undergo condensation with formaldehyde and 1,1-dinitroethane to form 3,5-di-(hydroxyalkyl)-4-(2,2-dinitropropylamino)-1,2,4-triazoles.

  3. 3.

    The use of an excess of the amine (10, 25%) or of the gem-dinitroethane (25, 50, and 100%) in the Mannich condensation reaction leads to difficulties in the isolation of the product.

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Literature cited

  1. S. S. Novikov, Z. Ya. Lapshina, V. A. Rudenko, and L. S. Semenenok, Izv. AN SSSR, Otd. khim. n., 1302 (1960).

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, U.S.S.R. Academy of Sciences, USSR

    V. M. Brusnikina, S. S. Novikov & V. A. Rudenko

Authors
  1. V. M. Brusnikina
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  2. S. S. Novikov
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  3. V. A. Rudenko
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Brusnikina, V.M., Novikov, S.S. & Rudenko, V.A. Aminotriazoles in the Mannich reaction. Russ Chem Bull 12, 1540–1542 (1963). https://doi.org/10.1007/BF00844115

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  • DOI: https://doi.org/10.1007/BF00844115

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