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A new method of preparing N-(amino-acyl) derivatives is extended to the preparation of N-(amino-acyl) derivatives of D-glucosamine containing residues of proline, L-tyrosine, and 6-aminohexanoic acid.
On the basis of the same method two variants are developed for the synthesis of N-peptide derivatives of amino sugars by the condensation of the amino sugar with the benzyloxycarbonyl derivative of the peptide and by the gradual building up of a peptide chain on an N-(amino-acyl) derivative of the amino sugar. In this way N-di-glycyi-, N-triglycyl-, and N-(L-alanylglycyl)-glucosamines were prepared.
KeywordsPeptide Sugar Proline Glucosamine Glycopeptide
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