Chemistry of Heterocyclic Compounds

, Volume 21, Issue 12, pp 1377–1381 | Cite as

Derivatives of 2,3-dihydpo-1H-1,5-benzodiazepine based on substituted 1,2-phenylenediamines and acetylarenes

  • V. D. Orlov
  • S. M. Desenko


Derivatives of 2,3-dihydro-1H-1,5-benzodiazepine were obtained by the reaction of 4-chloro-, 4-bromo- 3,5-dichloro-, and 4-cyano-substituted ortho-phenyl-enediamines with 4-R-acetophenones in the presence of concentrated sulfuric acid. Electron-withdrawing groups R increase the reaction rate and consequently promote the formation of a mixture of isomeric products. The structure of the compounds and the composition of their mixtures were established by PMR spectroscopy. The reaction mechanism is discussed.


Spectroscopy Organic Chemistry Sulfuric Acid Reaction Mechanism Concentrate Sulfuric Acid 
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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • V. D. Orlov
    • 1
  • S. M. Desenko
    • 1
  1. 1.A. M. Gor'kii State UniversityKhar'kov

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