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Negative ion mass spectra and structure of 4-substituted 1-phenyl-3-methyl-5-pyrazolones

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

This is the first study of the electron capture dissociative resonance (ECDR) mass spectra of 4-substituted 1-phenyl-3-methyl-5=pyrazolones. The major features of the fragmentation of these compounds under ECDR. conditions were found relative to their substituent properties. After loss of the methyl group from the nitrogen atom, the pyrazolone ring isomerizes to a pyrazole ring with localization of the negative charge on the oxygen atom of the carbonyl group. The intensity of the [M - Ch3]− fragment depends on the substituent properties.

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Authors and Affiliations

  1. Branch of the S. Ordzhonikidze All-Union Pharamaceutical Chemistry Research Institute, 142450, Staraya Kupavna

    A. I. Ermakov, A. A. Sorokin & V. G. Voronin

Authors
  1. A. I. Ermakov
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  2. A. A. Sorokin
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  3. V. G. Voronin
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Additional information

Communication 5 in the series on the Mass Spectroscopy of Biologically Active Compounds, For Communication 4, see [1].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1663–1670, December, 1985.

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Ermakov, A.I., Sorokin, A.A. & Voronin, V.G. Negative ion mass spectra and structure of 4-substituted 1-phenyl-3-methyl-5-pyrazolones. Chem Heterocycl Compd 21, 1368–1374 (1985). https://doi.org/10.1007/BF00842961

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  • DOI: https://doi.org/10.1007/BF00842961

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