Abstract
In 10 female pigs a partial unilateral ureteral obstruction was investigated for 3 weeks. The pigs were monitored with131I]I-iodohippuran scintigraphies before obstruction and once a week during the course of obstruction. Parenchymal and pelvic mean transit times were calculated by deconvolution analysis. Before the pigs were killed, pelvic pressure and volume were measured. During the course of obstruction there was a slight, but significant (P<0.05) difference in renographical split function between the 2 sides. Parenchymal transit times increased moderately ipsilaterally during the 1st and 2nd week after obstruction and a significant difference (P<0.02) appeared in the 2 nd week compared to the contralateral side, which was unchanged during the course of obstruction. Pelvic transit times increased steadily ipsilaterally during the course of obstruction and the opposite took place contralaterally. A fair correlation (r=0.65) was found between parenchymal transit time and pelvic baseline pressure. Pelvic transit times were prolonged at any time after obstruction and significantly correlated to the presence of obstruction. The study suggests that interpretation of the obstructed renogram will encounter analysis of both parenchymal and pelvic transit times in cases where renal function is moderately reduced.
Similar content being viewed by others
References
Britton KE, Nimmon CC, Whitfeld HN, Hendry WF, Wickham JEA (1979) Obstructive nephropathy: successful evaluation with radionuclides. Lancet 905:-7
Djurhuus JC, Sørensen SS, Jørgensen TM, Jensen FT (1985) Predictive value of pressure flow studies for the functional outcome of reconstructive surgery for hydronephrosis. Br J Urol 57:6–9
Gill WB, Curtis GA (1977) The influence of bladder fullness on upper urinary tract dimensions and renal excretory function. J Urol 117:573–576
Koff SA (1983) Determinants of progression and equilibrium in hydronephrosis. Urology 21:496–500
Lupton EW, Lawson RS, Shields RA, Testa HJ (1984) Diuresis renography and parenchymal transit times in the assessment of renal pelvic dilatation. Nucl Med Commun 5:451–9
Lupton EW, Richards D, Testa HJ, Gilpin A, Gosling JA, Barnard RJ (1985) A comparison of diuresis renography, the Whitaker test and renal morphology in idiopathic hydronephrosis. Br J Urol 57:119–23
Mortensen J (1986) Hydrodynamics of the pyeloureter of the pig. Thesis. Neurol Urodynamics 5:87–117
Mortensen J, Christiansen P, Harving N, Jensen FT, Djurhuus JC (1989) Pyeloureteral dynamics. Pelvic pressure and kidney function in long-term ureteric obstruction. Scand J Urol Nephrol (in press)
Mortensen J, Djurhuus JC, Møller JCF, Laursen H, Jensen FT (1983) The pressure volume relationship of renal pelvis in total obstruction in pigs. Urol Res 11:251–253
Neal DE, Simpson W, Bartholomew P, Keavey PM (1985) Comparison of dynamic computed tomography, diuresis renography and DTPA parenchymal transit time in assessment of dilatation of the upper urinary tract. Br J Urol 57:515–19
O'Reilly PH, Testa HJ, Lawson RS, Farrar DJ, Edwards EC (1978) Diuresis renography in equivocal urinary tract obstruction. Br J Urol 50:76–80
Paulson DF, Fraley EE (1973) Compensatory renal growth after unilateral ureteral obstruction. Kid Int 4:22–27
Poulsen EU, Frøkiær J, Jensen FT, Jorgensen TM, Nørgård JP, Djurhuus JC (1987) Diuresis renography and simultaneous renal pelvic pressure in hydronephrosis. J Urol 138:272–75
Whitaker RH (1973) Methods of assessing obstruction in dilated ureters. Br J Urol 45:15–22
Whitfield HN, Britton KE, Hendry WF, Nimmon CC, Wickham JEA (1978) The distinction between obstructive uropathy and nephropathy by radioisotope transit time. Br J Urol 50:433–36
Whitfield HN, Britton E, Hendry WF, Wickham JEA (1979) Frusemide intravenous urography in the diagnosis pelviureteric junction obstruction. Br J Urol 51:445–48.12
Whitfeld HN, Britton KE, Kelsey Fry I, Hendry WF, Nimmon CC, Travers P, Wickham JEA (1977) The obstructed kidney: Correlation between renal function and urodynamic assessment. Br J Urol 49:615–19
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Frøkiær, J., Jensen, F.T., Djurhuus, J.C. et al. The impact of unilateral ureteral obstruction on pelvic and parenchymal transit times in the pig kidney. Eur J Nucl Med 16, 349–352 (1990). https://doi.org/10.1007/BF00842791
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00842791