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An evaluation of99mTc-HMPAO uptake in cerebral gliomas —a comparison with X-ray CT

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Abstract

Nineteen patients with biopsy-proven cerebral gliomas were studied with99mTc-HMPAO single photon emission tomography (SPELT) imaging and X-ray computed tomography (CT). The uptake of99mTc-HMPAO was correlated with tumour size and morphology as shown by X-ray CT, and overall patient survival. It appears that uptake of99mTc-HMPAO is associated with larger, ill-defined tumours and was an adverse factor in patient survival. In those tumours with normal or increased uptake,99mTc-HMPAO imaging is useful in distinguishing the tumour margin from surrounding oedema.

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References

  • Anderson A, Holm S, Vorstrup S (1985) Tomographic brain imaging using SPELT and a new Tc99m-labeled oxime HM-PAO. Eur J Nucl Med 11: A5(A3)

  • Babich JW, Keeling F, Flower MA, Whitton A, Fielding S, Fullbrook A, Ott RJ, McCready VR (1988) Initial experience with 99mTc-HM-PAO in the study of brain tumors. Eur J Nucl Med 14:39–44

    Google Scholar 

  • Burger PC, Heinz ER, Shibata T, Kleihues P (1988) Topographic anatomy and CT correlations in the untreated glioblastoma multiforme. J Neurosurg 68:698–704

    Google Scholar 

  • Cronqvist S, Ingvar DH, Lassen NA (1965) Quantitative assessments of regional cerebral blood flow related to neurological findings. Acta Radiology 5:760–766

    Google Scholar 

  • Flower MA, Babich JW, Keeling F, Fielding S, Fullbrook A, Chittenden S, Cowley A, Repetto L, Whitton A, McCready VR (1989) Clinical evaluation of a new radioactive tracer (99mTcHM-PAO) for imaging regional cerebral blood flow in patients with brain tumours. In: Anderson WJ, Sheldon CD, Barbenal JC, Fisher AC, Gaylor JDS (eds) Blood flow in the brain. Clarenden, Oxford, Ch 6

    Google Scholar 

  • Harbert J (1984) The brain. In: Harbert J, DaRocha AFG (eds) Textbook of nuclear medicine volume 11: Clinical applications. Lea & Febiger, Philadelphia, Ch 4

    Google Scholar 

  • Hoffman TJ, McKenzie EH, Volkert WA, Laughlin MH, Holmes RA (1986) Validation of Tc-99m-d,1-hexamethyl propylene amine oxime (To-99m-d, 1-HM-PAO) as a regional cerebral blood flow agent: a microsphere study. J Nucl Med 27:1050 (abstr)

    Google Scholar 

  • Kung HF, Tramposch KM, Blau M (1983) A new brain perfusion imaging agent: [I-123] HIPDM: N,N,N′-Trimethyl-N′ [2-Hydroxy-3-Methyl-5-Iodobenzyl]-1, 3-Propanediamine. J Nucl Med 24:66–72

    Google Scholar 

  • Langen K-J, Herzog H, Rota E, Roosen N, Wieler H, Kiwit J, Kuwert T, Storch-Becker A, Feinendegen L (1987) Tomographic studies of rCBF with99-Tc-HM-PAO SPELT in comparison with PET in patients with primary brain tumors. Neurosurg Rev 10:23–24

    Google Scholar 

  • Lindegaard W, Skretting A, Hager B, Watne K, Lindegaard K-F (1986) Cerebral and cerebellar uptake of99m-Tc-(d, I)-hexamethyl-propylene amine oxime (HM-PAO) in patients with brain tumor studied by single photon emission computerized tomography. Eur J Nuc Med 12:417–420

    Google Scholar 

  • Neirinckx RD, Canning LR, Piper IM, Nowotnik DP, Pickett RD, Holmes RA, Volkert WA, Forster AM, Weisner PS, Marriett JA, Chaplin SB (1987) Technetium-99m d, l-HM-PAO: A new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med 28:191–202

    Google Scholar 

  • Nowotnik DP, Canning LR, Cumming SA (1985) Development of a Tc-99m-labeled radiopharmaceutical for cerebral blood flow imaging. Nucl Med Comm 6:499–506

    Google Scholar 

  • Pálvölgyi R (1969) Regional cerebral blood flow in patients with intra-cranial tumours. J Neurosurg 31:149–163

    Google Scholar 

  • Winchell HS, Baldwin RM, Lin TH (1980) Development of 1-123-labeled amines for brain studies: localisation of I-123 iodophenylalkyl amines in rat brain. J Nucl Med 21:940–946

    Google Scholar 

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Irvine, A.T., Flower, M.A., Ott, R.J. et al. An evaluation of99mTc-HMPAO uptake in cerebral gliomas —a comparison with X-ray CT. Eur J Nucl Med 16, 293–298 (1990). https://doi.org/10.1007/BF00842782

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  • DOI: https://doi.org/10.1007/BF00842782

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