Abstract
The cerebral distribution of99mTc-labeled d, l, hexamethyl-propylene-amine-oxime (99mTc-HMPAO) as a function of rCBF and time was examined in rats and in man. The results of this study confirm that99mTc-HMPAO is distributed in brain in proportion to rCBF. However, the rapid systemic breakdown of the tracer in blood results in considerable difficulties in the assessment of the arterial concentration of the parent compound; incomplete extraction of99mTc-HMPAO from blood to brain and significant efflux from brain represent further limitations in the use of this tracer for quantification of rCFB. Despite these limitations99mTc-HMPAO is of potential interest for a qualitative assessment of rCBF in specific clinical conditions.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andersen AR, Friberg H, Lassen NA, Kristensen K, Neirinckx RD (1988) Assessment of the arterial input curve for99mTc-d,l-HM-PAO by rapid octanol extraction. J Cereb Blood Flow Metab 8:S23
Bellini S, Piacentini M, Cafforio C, Rocca F (1979) Compensation of tissue absorption in emission tomography. IEEE Trans ASSP 27:213
Kuhl DE, Barrio JR, Huang SC, Selin C, Ackermann RE, Lear JL, Wu JL, Lin TH, Phelps ME (1982) Quantifying local cerebral blood flow by N-isopropyl-p-[123I] iodo-amphetamine (IMP) tomography. J Nucl Med 23:196
Kung HE, Blau M (1980) Regional intracellular pH shift: a proposed new mechanism for radiopharmaceutical uptake in brain and other tissues. J Nucl Med 21:147
Lassen NA, Andersen AR, Friberg L, Paulson OB (1988) The retention of [99mTc]-d,l-HM-PAO in the human brain after intracarotid bolus injection: a kinetic analysis. J Cereb Blood Flow Metab 8:S13
Lear JL (1988a) Quantitative local cerebral blood flow measurements with Technetium-99m HM-PAO: evaluation using multiple radionuclide digital quantitative autoradiography. J Nucl Med 29:1387
Lear JL (1988b) Initial cerebral HM-PAO distribution compared to LCBF: use of a model which considers cerebral HM-PAO trapping kinetics. J Cereb Blood Flow Metab 8:S31
Lucignani G, Nehlig A, Blasberg R, Patlak CS, Anderson L, Fieschi C, Fazio F, Sokoloff L (1985) Metabolic and kinetic considerations in the use of [125I] HIPDM for quantitative measurement of regional cerebral blood flow. J Cereb Blood Flow Metab 5:86
Matsuda H, Oba H, Seki H, Higashi S, Sumiya H, Tsuji S, Terada H, Imai K, Shiba K, Mori H, Hisada K (1988) Determination of flow and rate constants in a kinetic model of99mTc-Hexamethyl-Propylene Amine Oxime in the human brain. J Cereb Blood Flow Metab 8:S61
Neirinckx RD, Canning LR, Piper IM, Nowotnik DP, Pickett RD, Holmes RA, Volkert WA, Forster AM, Weisner PS, Marriott JA, Chaplin SB (1987) Technetium-99m d,l-HM-PAO: a new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion. J Nucl Med 28:191
Sakurada O, Kennedy C, Jehle J, Brown JD, Carbin GL, Sokoloff L (1978) Measurement of local cerebral blood flow with [14C] iodoantipyrine. Am J Physiol 239:H59
Sapirstein LA (1958) Regional blood flow by fractional distribution of indicators. Am J Physiol 193:168
Sharp PF, Smith FW, Gemmell HG, Lyall D, Evans NTS, Gvozdanovic D, Davidson J, Tyrrell DA, Pickett RD, Neirinckx RD (1986) Technetium-99m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow. J Nucl Med 27:171
Tramposh KM, Kung HF, Blau M (1983) Radioiodine labeled N,N,-dimethyl-N-(2-hydroxyl-3-alkil-5-iodobenzyl)-1,3-propanediamines for brain perfusion imaging. J Med Chem 28:71
Winchell HS, Baldwin RM, Lin TH (1980) Development of I-123labelled amines for brain studies: localization of I-123 iodophenylalkyl amines in rat brain. J Nucl Med 21:940
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lucignani, G., Rossetti, C., Ferrario, P. et al. In vivo metabolism and kinetics of99mTc-HMPAO. Eur J Nucl Med 16, 249–255 (1990). https://doi.org/10.1007/BF00842776
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00842776