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European Journal of Nuclear Medicine

, Volume 16, Issue 4–6, pp 205–212 | Cite as

Regional rates of myocardial fatty acid metabolism: comparison with coronary angiography and ventriculography

  • N. Schad
  • R. K. Wagner
  • J. Hallermeier
  • H. J. Daus
  • A. Vattimo
  • P. Bertelli
Original Article

Abstract

In 50 patients, 1 mCi123I phenylpentadecanoic acid (IPPA) was injected at peak ergometric stress and 1500 frames were acquired (1 frame/s) with a high count rate gamma camera. Parametric images of rates of decrease and increase for different time intervals after stress were compared with coronary angiography and LV ventriculography, separately evaluating the 3 main coronary territories: 18/150 territories supplied by normal coronaries presented rather homogeneous regional clearing rates, whereas a gradual decrease in clearing rates towards the end of the territory (frequently with peripheral defects) was seen in all 87/150 territories with significant coronary narrowing. In local correspondence to clearing defects, initial IPPA accumulations could be observed with later onset of clearing between 10 and 25 min. 44/150 territories presented abnormal clearing rates, mostly with a patchy pattern, with normal coronary anatomy, but all except one had LV dysfunction and a clinical diagnosis of Cadomyopathy, diabetes mellitus or hypertensive disease. Twenty four of the 41 patients with CAD had, in correspondence to a prior myocardial infarction, minimum or missing metabolic activity frequently in circumscribed zones, partly separated by bridges of still viable tissue with preserved but reduced clearing rates.

Key words

IPPA Fatty acid metabolism Coronary artery disease Cardiomyopathy Hypertensive disease 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • N. Schad
    • 1
    • 2
  • R. K. Wagner
    • 1
  • J. Hallermeier
    • 1
  • H. J. Daus
    • 1
  • A. Vattimo
    • 2
  • P. Bertelli
    • 2
  1. 1.Im Städtischen Krankenhaus PassauLehrkrankenhaus der Technischen Universität MünchenPassauGermany
  2. 2.Istituto di Scienze Eidologiche e RadiologicheUniversità di SienaItaly

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