Histotopography of changes in brain enzyme activity produced by fluphenazine in rats
- 15 Downloads
Fluphenazine in doses of 1 and 5 mg/kg reduced the activity of respiratory enzymes (succinate, isocitrate, NAD · H2, and NADP · H2 dehydrogenases) in various brain structures of rats 3 h after a single subcutaneous injection; the most marked changes in enzyme activity were observed in the limbic and frontal regions of the cortex.
Key Wordsfluphenazine enzymes brain
Unable to display preview. Download preview PDF.
- 1.G. I. Absava and V. A. Markin, Farmakol. Toksikol., No. 6, 653 (1973).Google Scholar
- 2.M. N. Livanov et al., in: The Frontal Lobes and Regulation of Psychological Processes [in Russian], Moscow (1966), p. 176.Google Scholar
- 3.V. A. Markin and V. A. Arefolov, Byull. Éksp. Biol. Med., No. 4, 55 (1972).Google Scholar
- 4.V. A. Markin and V. S. Mitrofanov, Farmakol. Toksikol., No. 1, 10 (1975).Google Scholar
- 5.S. Gabay and S. Harris, Agressologie,9, 79 (1968).Google Scholar
- 6.A. Chowdhury, H. Rogers, A. Skinner, et al., Brit. J. Pharmacol.,37, 459 (1969).Google Scholar
- 7.L. Fahich and O. Shemisa, Acta Pharmacol. (Copenhagen),6, 156 (1970).Google Scholar