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Bulletin of Experimental Biology and Medicine

, Volume 80, Issue 6, pp 1443–1445 | Cite as

Histotopography of changes in brain enzyme activity produced by fluphenazine in rats

  • B. I. Lyubimov
  • V. A. Markin
  • V. S. Mitrofanov
Pharmacology
  • 15 Downloads

Abstract

Fluphenazine in doses of 1 and 5 mg/kg reduced the activity of respiratory enzymes (succinate, isocitrate, NAD · H2, and NADP · H2 dehydrogenases) in various brain structures of rats 3 h after a single subcutaneous injection; the most marked changes in enzyme activity were observed in the limbic and frontal regions of the cortex.

Key Words

fluphenazine enzymes brain 

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Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • B. I. Lyubimov
  • V. A. Markin
  • V. S. Mitrofanov

There are no affiliations available

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