Bulletin of Experimental Biology and Medicine

, Volume 80, Issue 6, pp 1443–1445 | Cite as

Histotopography of changes in brain enzyme activity produced by fluphenazine in rats

  • B. I. Lyubimov
  • V. A. Markin
  • V. S. Mitrofanov


Fluphenazine in doses of 1 and 5 mg/kg reduced the activity of respiratory enzymes (succinate, isocitrate, NAD · H2, and NADP · H2 dehydrogenases) in various brain structures of rats 3 h after a single subcutaneous injection; the most marked changes in enzyme activity were observed in the limbic and frontal regions of the cortex.

Key Words

fluphenazine enzymes brain 


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Literature Cited

  1. 1.
    G. I. Absava and V. A. Markin, Farmakol. Toksikol., No. 6, 653 (1973).Google Scholar
  2. 2.
    M. N. Livanov et al., in: The Frontal Lobes and Regulation of Psychological Processes [in Russian], Moscow (1966), p. 176.Google Scholar
  3. 3.
    V. A. Markin and V. A. Arefolov, Byull. Éksp. Biol. Med., No. 4, 55 (1972).Google Scholar
  4. 4.
    V. A. Markin and V. S. Mitrofanov, Farmakol. Toksikol., No. 1, 10 (1975).Google Scholar
  5. 5.
    S. Gabay and S. Harris, Agressologie,9, 79 (1968).Google Scholar
  6. 6.
    A. Chowdhury, H. Rogers, A. Skinner, et al., Brit. J. Pharmacol.,37, 459 (1969).Google Scholar
  7. 7.
    L. Fahich and O. Shemisa, Acta Pharmacol. (Copenhagen),6, 156 (1970).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • B. I. Lyubimov
  • V. A. Markin
  • V. S. Mitrofanov

There are no affiliations available

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