Bulletin of Experimental Biology and Medicine

, Volume 80, Issue 6, pp 1438–1439 | Cite as

Pyruvate kinase activity in the liver of rats with induced tumors

  • G. P. Gorban'
Biochemistry and Biophysics


The activity of pyruvate kinase (PK) and its isozymes was studied in the liver of rats with macroscopically visible tumors induced by p-dimethylaminoazobenzene. At the same time the action of a prolonged dietary intake of NaF by the rats on PK was studied. An increase in activity of the M-isozyme of PK during development of a malignant liver tumor was demonstrated. An excess of NaF in the diet of rats prevents the increase in the activity of this isozyme.

Key Words

pyruvate kinase and its isozymes hepatoma fluorine 

Literature Cited

  1. 1.
    G. P. Gorban', O. D. Karpilovs'ka, L. I. Laevs'ka, et al., Ukr. Biokhim. Zh., No. 4, 473 (1973).Google Scholar
  2. 2.
    O. G. Prokof'eva, Sov. Vrach. Sbornik, No. 10, 1 (1947).Google Scholar
  3. 3.
    S. Bailey, F. Stirpe, and C. Taylor, Biochem. J.,108, 427 (1968).Google Scholar
  4. 4.
    T. Bücher and G. Pfleiderer, in: Methods in Enzymology (ed. by S. P. Colowick and N. O. Kaplan), Vol. 1, Academic Press, New York (1955), p. 435.Google Scholar
  5. 5.
    H. Carminatti, L. De Asua, E. Recondo, et al., J. Biol. Chem.,243, 3051 (1968).Google Scholar
  6. 6.
    A. Doberenz, A. Kurnick, E. Kurtz, et al., Proc. Soc. Exp. Biol. (New York),117, 689 (1964).Google Scholar
  7. 7.
    B. Hess and C. Kutzbach, Hoppe-Seyler's Z. Physiol. Chem.,352, 453 (1971).Google Scholar
  8. 8.
    S. Janagi, T. Kamija, Y. Ikehara, et al., Gann,62, 283 (1971).Google Scholar
  9. 9.
    T. Tanaka, Y. Harano, F. Sue, and H. Morimura, J. Biochem. (Tokyo),62, 71 (1967).Google Scholar
  10. 10.
    R. Walker and V. Potter, Adv. Enzyme Reg.,10, 339 (1971).Google Scholar
  11. 11.
    O. Warburg and W. Christian, Biochem. Z.,310, 384 (1942).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • G. P. Gorban'

There are no affiliations available

Personalised recommendations