Abstract
The effect of catecholamines on chain peroxidation of lipids in the liver mitochondrial membranes in the presence of Fe++ ions was studied by a very weak chemiluminescence method. Catecholamines between concentrations of 10−6 and 10−4 M were shown to inhibit this process. By a mathematical investigation of the kinetics of the process constants of antioxidative activity of the catecholamines were calculated, as follows: for noradrenalin 1.13·104 M−1, adrenalin 1.04·104 M−1, dopamine 7.6·103 M−1, and dopa 5·103 M−1. The antioxidative action of the catecholamines was linked with the presence of a free phenol group in their molecule. The mechanism of inhibition consists of interaction between catecholamines and free radicals leading the oxidation chains. It is postulated that the antioxidative action of catecholamines may have an important role in the regulation of the permeability of biological membranes.
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Sergeev, P.V., Seifulla, R.D., Dunaev, V.G. et al. Effect of adrenalin, noradrenalin, dopamine, dopa, and phenylalanine on peroxidation of lipids in liver mitochondrial membranes. Bull Exp Biol Med 80, 1428–1431 (1975). https://doi.org/10.1007/BF00842628
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DOI: https://doi.org/10.1007/BF00842628