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European Journal of Nuclear Medicine

, Volume 24, Issue 6, pp 674–677 | Cite as

Assessment of endogenous dopamine release by methylphenidate challenge using iodine-123 iodobenzamide single-photon emission tomography

  • J. Booij
  • P Korn
  • D. H. Linszen
  • E. A. van Royen
Short Communication

Abstract

This double-blind, placebo-controlled study assessed pharmacologically induced endogenous dopamine (DA) release in healthy male volunteers (n=12). Changes in endogenous DA release after injection of the psychostimulant drug methylphenidate were evaluated by single-photon emission tomography (SPET) and constant infusion of iodine-123 iodobenzamide ([123I]IBZM), a D2 receptor radioligand that is sensitive to endogenous DA release. Methylphenidate induced displacement of striatal [123I]IBZM binding, resulting in a significantly decrease in the specific to non-specific [123I]IBZM uptake ratio (average: 8.6%) in comparison with placebo (average: −1.9%). Moreover, injection of methylphenidate induced significant behavioural responses on the following items: excitement, anxiety, tension, and mannerisms and posturing. The results of this study demonstrate the feasibility of using constant infusion of [123I]IBZM and SPET imaging to measure endogenous DA release after methylphenidate challenge and to investigate neurochemical aspects of behaviour.

Key words

Single-photon emission tomography D2 receptors Iodine-123 iodobenzamide Methylphenidate Constant infusion 

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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • J. Booij
    • 1
  • P Korn
    • 1
  • D. H. Linszen
    • 2
  • E. A. van Royen
    • 1
  1. 1.Graduate School of Neurosciences, Department of Nuclear MedicineAcademic Medical CenterAmsterdamThe Netherlands
  2. 2.Department of PsychiatryAcademic Medical CenterAmsterdamThe Netherlands

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