Abstract
Calibration for three-dimensional positron emission tomography (3D PET) using a uniform cylinder and cross-calibration with aliquots requires correction for scatter and attenuation. Thus the accuracy of thecalibration is dependent on the scatter correction method, and on the applicability of the scatter correction for different regions of the body. A method has been developed which provides a calibration which does not require correction for scatter or attenuation, making it generally applicable and independent of the scatter correction. The method has been previously described for measurement of the absolute sensitivity of tomography devices. This approach has been extended to give a calibration of the PET camera “in air” in units of kBq/pixel. The reconstructed images are multiplied by this factor to, give accurate activity concentrations, after attenuation and scatter correction. The method has been used with a fully 3D filtered back-projection (reprojection) algorithm and iterative convolution-subtraction scatter correction on data from an ECAT 953B. Using this method 3D PET images have been calibrated te, within ±5% accuracy, but this is highly dependent on the accuracy of the scatter correction. The method described here is practical and provides a means of calibrating a 3D PET system without the need for correction for scatter or attenuation of the calibration data.
References
Thompson CJ. The effect of collimation on scatter fraction in multi-slice PET.IEEE Trans Nucl Sci 1988; 35: 598–602.
Eichling JO, Higgins CS, Ter-Pogossian MM. Determination of radionuclide concentrations with positron CT scanning (PETT): concise communication.J Nucl Med 1977; 18: 845–847.
Bailey DL, Joncs T, Spinks TJ. A method for measuring the absolute sensitivity of positron emission tomographie seautiers.Eur J Nucl Med 1991; 18: 374–379.
Bailey DL, Zito F, Gilardi M-C, Savi AR, Fazio F, Jones T. Performance comparison of a state-of-the-art neuro-SPET scanner and a dedicated neuro-PET scanner.Eur J Nucl Med 1994; 21: 381–387.
Kinahan PE, Rogers JG. Analytic 3-D image reconstruction using all detected events.IEEE Trans Nucl Sci 1989; NS-36: 964–968.
Hubbell JH. Photon cross sections, attenuation coefficients, and energy absorption coefficients from 10 keV to 100 GeV. National Bureau of Standards, US Dept of Commerce, 1969.
Bailey DL, Meikle SR. A convolution-subtraction scatter correction method for 3D PET.Phys Med Biol 1994; 39: 411–424.
Townsend DW, Choi Y, Sashin D, Mintun M. An investigation of practical scatter correction techniques for 3D PET [abstract].J Nucl Med 1994; 35: 50P.
Bergström M, Eriksson L, Bohm C, Blomqvist G, Litton J-E. Correction for scattered radiation in a ring detector positron camera by integral transformation of the projections.J Comput Assist Tomogr 1983; 7: 42–50.
Hubbell JH. A power series buildup factor formulation. Application to rectangular and off-axis disk source problems.J Res NBS 1963; 67C: 291–306.
Wu RK, Siegal JA. Absolute quantitation of radioactivity using the buildup factor.Med Phys 1984; 11: 189–192.
Shao L, Karp JS. Cross-plane scattering correction — point source deconvolution in PET.IEEE Trans Med Imag 1991; MI-10: 234–239.
Lercher MJ, Wienhard K. Scatter correction in 3-D PET.IEEE Trans Med Imag 1994; MI-13: 649–657.
Shao L, Freifelder R, Karp JS. Triple energy window scatter correction technique in PET.IEEE Trans Med Imag 1994; 13: 641–648.
Cherry SR, Meikle SR, Hoffman EJ. Correction and characterization of scattered events in three-dimensional PET using scanners with retractable septa.J Nucl Med 1993; 34: 671–678.
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Bailey, D.L., Jones, T. A method for calibrating three-dimensional positron emission tomography without scatter correction. Eur J Nucl Med 24, 660–664 (1997). https://doi.org/10.1007/BF00841405
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DOI: https://doi.org/10.1007/BF00841405