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Journal of Neurology

, Volume 239, Issue 1, pp 46–48 | Cite as

Muscle siderosis in AIDS: a marker for macrophage dysfunction?

  • Catherine Lacroix
  • Gérard Said
Original Communications

Summary

We have observed numerous iron granules in muscle fibres, endothelial cells and macrophages of muscle biopsy specimens of 21 out of 41 AIDS patients with different patterns of muscle involvement. All patients were severely immunodepressed. We report on our findings and discuss the mechanism of muscle siderosis that may point to deterioration of some functions of macrophages at a late stage of HIV infection.

Key words

AIDS Iron granule deposits Muscle pathology Macrophage dysfunction 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Catherine Lacroix
    • 1
  • Gérard Said
    • 1
  1. 1.Service de Neurologie et Laboratoire de NeuropathologieHôpital de BicêtreLe Kremlin Bicêtre CedexFrance

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