Journal of Neurology

, Volume 239, Issue 1, pp 46–48 | Cite as

Muscle siderosis in AIDS: a marker for macrophage dysfunction?

  • Catherine Lacroix
  • Gérard Said
Original Communications


We have observed numerous iron granules in muscle fibres, endothelial cells and macrophages of muscle biopsy specimens of 21 out of 41 AIDS patients with different patterns of muscle involvement. All patients were severely immunodepressed. We report on our findings and discuss the mechanism of muscle siderosis that may point to deterioration of some functions of macrophages at a late stage of HIV infection.

Key words

AIDS Iron granule deposits Muscle pathology Macrophage dysfunction 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bailey RO, Turok DI, Jaufmann BP, Singh JK (1987) Myositis and acquired immunodeficiency syndrome. Hum Pathol 18:749–751PubMedGoogle Scholar
  2. 2.
    Baldwin GC, Fleischmann J, Chung Y, Koyanagi Y, Chen ISY, Golde DW (1990) Human immunodeficiency virus causes mononuclear phagocyte dysfunction. Proc Natl Acad Sci USA 87:3933–3937PubMedGoogle Scholar
  3. 3.
    Behar R, Wiley C, McCutchar JA (1987) Cytomegalovirus polyradiculoneuropathy in acquired immune deficiency syndrome. Neurology 37:557–562PubMedGoogle Scholar
  4. 4.
    Bender BS, Davidson BL, Kline R, Brown C, Quinn TC (1988) Role of the mononuclear phagocyte system in the immunopathogenesis of human immunodeficiency virus infection and acquired immunodeficiency syndrome. Rev Infect Dis 10:1142–1154PubMedGoogle Scholar
  5. 5.
    Bessen LJ, Greene JB, Louie E, Seitzman P, Weinberg H (1988) Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC. N Engl J Med 318:708Google Scholar
  6. 6.
    Bowen DL, Lane HC, Fauci AS (1985) Immunopathogenesis of the acquired immunodeficiency syndrome. Ann Intern Med 103:704–709PubMedGoogle Scholar
  7. 7.
    Centers for Disease Control (CDC) (1985) Classification system for human-T-lymphotropic virus type III/lymphadenopathy-associated virus infections. MMWR 35:334Google Scholar
  8. 8.
    Cohen IS, Anderson DW, Virmani R, et al (1986) Congestive cardiomyopathy in association with the acquired immunodeficiency syndrome. N Engl J Med 15:628–629Google Scholar
  9. 9.
    Cornblath DR, McArthur JC (1988) Predominantly sensory neuropathy in patients with AIDS and AIDS-related complex. Neurology 38:794–795PubMedGoogle Scholar
  10. 10.
    Dalakas MC, Pezeshkopour GH (1988) Neuromuscular diseases associated with human immunodeficiency virus infection. Ann Neurol 23 [Suppl]: S38-S48PubMedGoogle Scholar
  11. 11.
    Dubowitz V, Brooke MH (1973) Muscle biopsy; a modern approach. In: Major problems in neurology. Saunders, London, pp 20–33Google Scholar
  12. 12.
    Engel AG, Banker BQ (1986) Myology. McGraw-Hill, New York, pp 1724–1728Google Scholar
  13. 13.
    Ganter P, Jolles G (19969) Histochimie normale et pathologique. Gauthier-Villars, Paris, pp 826–840Google Scholar
  14. 14.
    Gaut P, Wong PK, Meyer RD (1988) Pyomyositis in a patient with the acquired immunodeficiency syndrome. Arch Intern Med 148:1608–1610PubMedGoogle Scholar
  15. 15.
    Gendelman He, Orenstein JM, Baca LM, Weiser B, Burger H, Kalter DC, et al (1989) The macrophage in the persistence and pathogenesis of HIV infection. AIDS 3:475–495PubMedGoogle Scholar
  16. 16.
    Gertner E, Thurn JR, Williams DN, Simpson M, Balfour MH et al (1989) Zidovudine associated myopathy. Am J Med 86:814–818PubMedGoogle Scholar
  17. 17.
    Gonzales MF, Olney RK, So YT, Greco CM, McQuinn BA, Miller RG, et al (1988) Subacute structural myopathy associated with human immunodeficiency virus infection. Arch Neurol 45:585–587PubMedGoogle Scholar
  18. 18.
    Gorard DA, Henry K, Guiloff RJ (1988) Necrotizing myopathy and zidovudine. Lancet I:1050Google Scholar
  19. 19.
    Helbert M, Fletcher T, Peddle B, Harris JRW, Pinching AJ (1988) Necrotizing myopathy and zidovudine. Lancet II:689–690Google Scholar
  20. 20.
    Lacroix-Ciaudo C, Said G (1990) Pigment ferrique intramusculaire au cours de l'infection par le VIH (abstract). Rev Neurol (Paris) 146:169Google Scholar
  21. 21.
    Martini RM de, Parker JW (1989) Immunologic alterations in human immunodeficiency virus infection: a review. J Clin Lab Anal 3:56–70PubMedGoogle Scholar
  22. 22.
    Mastaglia FL, Ojeda VJ (1985) Inflammatory myopathies. I. Ann Neurol 17:215–227PubMedGoogle Scholar
  23. 23.
    Panegyres PK, Tan N, Kakulas BA, Armstrong JA, Hollingsworth P (1988) Necrotizing myopathy and zidovudine. Lancet 1:1050–1051PubMedGoogle Scholar
  24. 24.
    Said G, Lacroix-Ciaudo C, Fujimura H, Blas C, Faux N (1988) The peripheral neuropathy of necrotizing arteritis: a clinicopathologic study. Ann Neurol 23:461–465PubMedGoogle Scholar
  25. 25.
    Said G, Lacroix C, Chemouilli P, Goulon-Goéau C, Roullet E, Penaud D, Brouker T de, Meduri G, Vincent D, Torchet M, Vittcoq DE, Leport C, Vildé JL (1991) Cytomegalovirus neuropathy in acquired immunodeficiency syndrome: a clinical and pathological study. Ann Neurol 29:139–146PubMedGoogle Scholar
  26. 26.
    Simpson DM, Bender AN (1988) Human immunodeficiency virus-associated myopathy: analysis of 11 patients. Ann Neurol 24:79–84PubMedGoogle Scholar
  27. 27.
    Stern R, Gold J, Dicarlo EF (1987) Myopathy complicating the acquired immune deficiency syndrome. Muscle Nerve 10:318–322PubMedGoogle Scholar
  28. 28.
    Vallat JM, Loubet R, Leboutet MJ, Loubet A (1978) Hemosiderin deposition in muscle. Acta Neuropathol (Berl) 42:153–156Google Scholar
  29. 29.
    Watts RA, Hoffbrand BI, Paton DF, Davis JC (1987) Pyomyositis associated with human immunodeficiency virus infection. BMJ 294:1524–1525PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Catherine Lacroix
    • 1
  • Gérard Said
    • 1
  1. 1.Service de Neurologie et Laboratoire de NeuropathologieHôpital de BicêtreLe Kremlin Bicêtre CedexFrance

Personalised recommendations