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An association between multiple sclerosis and type I diabetes mellitus

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Summary

We report five patients who had multiple sclerosis (MS) associated with type I diabetes mellitus (TODM). Examination of the Israeli National Neurological Disease Register revealed the prevalence of TODM among 334 MS patients under the age of 30 years to be 8.98 per 1,000. This is significantly higher than the prevalence of TODM in the general population of Israel for the same age group, which is 0.095 per 1,000. MS and TODM share clinical, epidemiological and immunological features, and both diseases have a target site that is neuroectodermal in origin. The association between these two putative autoimmune diseases may suggest a similar pathogenetic mechanism.

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References

  1. Aita JF, Snyder DH, Reichl W (1974) Myasthenia gravis and multiple sclerosis: an unusual combination of diseases. Neurology 24:72–75

    PubMed  Google Scholar 

  2. Alter M, Sawyer GT, Latham K (1970) The frequency of diabetes mellitus in families of patients with multiple sclerosis. Neurology 20:619–621

    PubMed  Google Scholar 

  3. Antel JP, Arnason BGW (1987) Demyelinating disorders. In: Braunwald E, Isselbacher KJ, Petersdorf RG, Wilson JD, Martin JR, Fauci AS (eds) Harrison's principles of internal medicine, 11th edn. McGraw-Hill, New York, pp 1995–2000

    Google Scholar 

  4. Berk MA, Sloan JB, Fretzin DF (1988) Lupus erythematosus in a patient with a long standing multiple sclerosis. J Am Acad Dermatol 19:969–972

    PubMed  Google Scholar 

  5. Brand-Auraban A (1956) Juvenile diabetes in Israel. Harefuah 50:108–109

    PubMed  Google Scholar 

  6. Cahill GF, McDevitt HO (1981) Insulin-dependent diabetes mellitus: the initial lesion. N Engl J Med 304:1454–1465

    PubMed  Google Scholar 

  7. Cohen T, Nelken L, Wolfsohn H (1970) Juvenile diabetes mellitus in immigrant populations in Israel. Diabetes 19:585–590

    PubMed  Google Scholar 

  8. Eisenbarth GS, Connelly J, Soeldner JS (1987) The “natural” history of type I diabetes. Diabetes Metab Rev 3:873–891

    PubMed  Google Scholar 

  9. Gamble DR (1980) The epidemiology of insulin dependent diabetes with particular reference to the relationship of virus infection to its etiology. Epidemiol Rev 2:49–70

    PubMed  Google Scholar 

  10. Hafler DA, Weiner HL (1989) MS: a CNS and systemic autoimmune disease. Immunol Today 10:104–107

    PubMed  Google Scholar 

  11. Henneman DH, Altschule MD, Gonez RM, Alexander L (1954) Carbohydrate metabolism in brain diseases. I. Glucose metabolism in multiple sclerosis. Arch Neurol Psychiatr 72:688–695

    Google Scholar 

  12. Holmes FF, Stubbs DW, Larsen WE (1967) Systemic lupus erythematosus and multiple sclerosis in identical twins. Arch Intern Med 119:302–304

    PubMed  Google Scholar 

  13. Kahana E, Leibowitz Y, Schoenberg BS, Alter M (1982) Israeli National Neurological Disease Register. Neuroepidemiology 1:239–248

    Google Scholar 

  14. Kurtzke JF (1980) Epidemiological contributions to multiple sclerosis: an overview. Neurology 30:61–79

    PubMed  Google Scholar 

  15. Kurtzke JF (1983) Some epidemiological trends in multiple sclerosis. Trends Neurosci 6:75–80

    Google Scholar 

  16. Laborde JM, Dando WA, Teetzen ML (1988) Climate, diffuse solar radiation and multiple sclerosis. Soc Sci Med 27:231–238

    PubMed  Google Scholar 

  17. Lo R, Feasby TE (1983) Multiple sclerosis and autoimmune diseases. Neurology 33:97–98

    PubMed  Google Scholar 

  18. McDonald WI, Halliday AM (1977) Diagnosis and classification of multiple sclerosis. Br Med Bull 33:4–8

    PubMed  Google Scholar 

  19. Patrick SL, May CS, LaPorte RE (1989) The world of insulindependent diabetes mellitus: what international studies reveal about the etiology and national history of IDDM. Diabetes Metab Rev 5:571–578

    PubMed  Google Scholar 

  20. Pearson ES, Hartley HO (eds) Biometrical tables for statisticians. Cambridge University Press, Cambridge

  21. Roberts H (1966) On the etiology, rational treatment and prevention of multiple sclerosis. South Med J 59:940–950

    PubMed  Google Scholar 

  22. Rose AS, Ellison GW, Myers LW, Tourtellotte WW (1976) Criteria for the clinical diagnosis of multiple sclerosis. Neurology 26 [Suppl 20]:20–22

    PubMed  Google Scholar 

  23. Somer H, Muller K, Kinnunen E (1989) Myasthenia gravis associated with multiple sclerosis. Epidemiological survey and immunological findings. J Neurol Sci 89:37–48

    PubMed  Google Scholar 

  24. Statistical Abstract of Israel (1950) Central Bureau of Statistics, Jerusalem

  25. Tanphaichitr K (1980) Multiple sclerosis associated with eosinophilic vasculitis, pericarditis and hypocomplementemia. Arch Neurol 37:314–315

    PubMed  Google Scholar 

  26. Walker A, Cudworth AG (1980) Type I (insulin-dependent) diabetic multiplex families: mode of genetic transmission. Diabetes 29:1036–1039

    PubMed  Google Scholar 

  27. Warren S, Warren KG (1981) Multiple sclerosis and associated diseases: a relationship of diabetes mellitus. Can J Neurol Sci 8:35–39

    PubMed  Google Scholar 

  28. Warren S, Warren KG (1982) Multiple sclerosis and diabetes mellitus: further evidence of relationship. Can J Neurol Sci 9:415–419

    PubMed  Google Scholar 

  29. Weiner HL, Hauser SL (1982) Neuroimmunology. I. Immunoregulation in neurological disease. Ann Neurol 11:437–449

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Hadassah University Hospital, and Hebrew University-Hadassah Medical School, P.O. Box 12000, Jerusalem, Israel

    Eliyahu Wertman, Nelly Zilber & Oded Abramsky

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  1. Eliyahu Wertman
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  2. Nelly Zilber
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  3. Oded Abramsky
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Wertman, E., Zilber, N. & Abramsky, O. An association between multiple sclerosis and type I diabetes mellitus. J Neurol 239, 43–45 (1992). https://doi.org/10.1007/BF00839211

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  • DOI: https://doi.org/10.1007/BF00839211

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