European Journal of Nuclear Medicine

, Volume 22, Issue 2, pp 116–121 | Cite as

Metabolism of nitrogen-13 labelled ammonia in different conditions in dogs, human volunteers and transplant patients

  • Guy Bormans
  • Alex Maes
  • Willem Langendries
  • Johan Nuyts
  • Mathias Vrolix
  • Johan Vanhaecke
  • Christiaan Schiepers
  • Michel De Roo
  • Luc Mortelmans
  • Alfons Verbruggen
Original Article
  • 26 Downloads

Abstract

To investigate the rate of metabolism of nitrogen-13 labelled ammonia (13NH3) in different conditions, we have determined the relative amount of unchanged13NH3 in the blood of dogs, volunteers and transplant patients at different times following injection. In dogs, the determinations were made under basal conditions, during adenosine administration and after coronary occlusion. The results show that adenosine administration increases the metabolic rate whereas coronary occlusion does not affect13NH3 metabolism. For both human volunteers and transplant patients the metabolic rate of13NH3 was assessed under basal conditions and during adenosine administration.13NH3 metabolism proceeds faster in transplant patients than in volunteers under both conditions. Adenosine administration causes a faster13NH3 turnover in volunteers but not in transplant patients. Application of individual metabolite correction resulted in a 16% decrease in the calculated blood flow compared to uncorrected values. A smaller difference (5%) was observed between correction with mean metabolite values and individually acquired metabolite values.

Key words

13NH3 metabolism Positron emission tomography Cardiac transplantation Coronary occlusion Adenosin 

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Guy Bormans
    • 1
  • Alex Maes
    • 2
  • Willem Langendries
    • 1
  • Johan Nuyts
    • 2
  • Mathias Vrolix
    • 3
  • Johan Vanhaecke
    • 3
  • Christiaan Schiepers
    • 2
  • Michel De Roo
    • 2
  • Luc Mortelmans
    • 2
  • Alfons Verbruggen
    • 1
  1. 1.Laboratory of Radiopharmaceutical Chemistry FFWUniversity Hospital GasthuisbergLeuvenBelgium
  2. 2.Department of Nuclear MedicineUniversity Hospital GasthuisbergLeuvenBelgium
  3. 3.Department of CardiologyUniversity Hospital GasthuisbergLeuvenBelgium

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