Abstract
Changes in weight indices for different parts of the heart, the area of cross sections of the myocytes, and vascularization of the myocardium during adaptation to hypoxia were studied in experiments on rats exposed to high-altitude hypoxia (3200 m above sea level). The morphological manifestation of compensatory and adaptive reactions of the rat heart to hypoxia is an increase in its weight, chiefly on account of hypertrophy of the myocardium of the right ventricle. Increasing hypertrophy of the myocardium is accompanied by the corresponding increase in its vascularization.
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Literature Cited
N. A. Agadzhanyan, in: Mountains and Resistance of the Organism, edited by M. M. Mirrakhimov [in Russian], Moscow (1970), pp. 21–65.
M. A. Aliev, in: Effects of High Altitudes on the Organism [in Russian], Frunze (1961), pp. 13–22.
V. Kh. Anestiadi and S. P. Russu, Kardiologiya, No. 10, 30 (1975).
Z. I. Barbashova, Acclimatization to Hypoxia and Its Physiological Mechanism [in Russian], Moscow-Leningrad (1960).
G. I. Il'in, Arkh. Patol., No. 8, 97 (1956).
M. M. Mirrakhimov, The Cardiovascular System under Mountain Conditions [in Russian], Leningrad (1968), pp. 18–95.
M. M. Mirrakhimov and N. Ya. Yusupova, Kardiologiya, No. 10, 39 (1975).
F. Z. Meerson, Kardiologiya, No. 4, 5 (1972).
A. R. Fishman, S. Lahiri and N. S. Cherniack, Proceedings of the International Union of Physiological Sciences, Vol. 10, Amsterdam (1974) p. 277.
E. Grandjean, in: Association des Physiologistes de Langue Francaise. 16-e Reunion, Paris (1948), p. 113.
C. Harrison and P. Wood, Br. Heart J.11, 105 (1949).
E. Opitz and G. Thews, Arch. Kreislaufforsch.,18, 137 (1952).
E. Meda, Aspetti Fisiologici dell'Ipossia nell'Uomo: l'Acclimatazione all'Alta Quota, Florence (1957).
D. Penaloza, F. Sime, and L. Ruiz, in: High-Altitude Physiology: Cardiac and Respiratory Aspects, edited by R. Porter and T. Knight, London (1971), p. 41.
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Kononova, V.A. Structural changes in the rat myocardium during adaptation to mountain hypoxia. Bull Exp Biol Med 88, 1228–1231 (1979). https://doi.org/10.1007/BF00838216
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DOI: https://doi.org/10.1007/BF00838216