Advertisement

Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 4, pp 1191–1193 | Cite as

Action of morphine on reproduction and immunological status in mice

  • I. N. Maiskii
  • G. P. Airapet'yan
  • A. I. Maiskii
  • R. B. Gudkova
  • É. G. Skryabina
  • T. A. Agafonova
  • S. A. Skhodova
  • Yu. I. Chekanova
Experimental Biology
  • 15 Downloads

Abstract

The course of embryogenesis is disturbed in CBA mice during prolonged administration of morphine. There is a parallel decrease in the level of antibody-synthesizing cells and a significant fall in cooperative interaction between T-and B-lymphocytes in response to injection of sheep's red blood cells. Meanwhile stimulation of bone marrow cells and specific sensitization of producers of migration inhibition factor to antigen from the brain of mice treated with morphine are observed.

Key Words

reproduction immunological status 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    V. E. Klusha, Khim.-Farmats. Zh., No. 1 3 (1978).Google Scholar
  2. 2.
    I. E. Kovalev, Khim.-Farmat. Zh., No. 12, 3 (1977).Google Scholar
  3. 3.
    I. N. Maiskii, P. V. Sergeev, T. A. Pokrovskaya, et al., in: Proceedings of the 2nd International Symposium [in Russian], Sofia, Bulgaria (1973), pp. 638–645.Google Scholar
  4. 4.
    I. N. Maiskii, T. A. Pokrovskaya, L. P. Fil'kova, et al., in: Proceedings of the 3rd International Symposium [in Russian], Sofia, Bulgaria (1978), pp. 792–798.Google Scholar
  5. 5.
    T. Cicero, R. Bell, E. Meyer, et al., J. Pharmacol. Exp. Ther.,200, 76 (1977).Google Scholar
  6. 6.
    G. Cohn, J. Cramer, and W. Brige, Proc. Soc. Exp. Biol. (N. Y.),147, 664 (1974).Google Scholar
  7. 7.
    J. David, Proc. Nat. Acad. Sci. USA,56, 72 (1966).Google Scholar
  8. 8.
    R. J. Hitzermann and H. Loh, Res. Commun. Chem. Pathol. Pharmacol.,12, 237 (1976).Google Scholar
  9. 9.
    G. Husby, P. E. Peirce, and R. C. Williams, Ann Intern. Med.,83, 801 (1975).Google Scholar
  10. 10.
    T. Nakajiama, J. Sasano, M. Keida, et al., Jpn. J. Pharmacol,25, 367 (1975).Google Scholar
  11. 11.
    A. Reif and J. M. Allen, Nature,209, 521 (1966).Google Scholar
  12. 12.
    D. A. Ringl and B. L. Herdon, J. Immunol.,115, 876 (1975).Google Scholar
  13. 13.
    V. S. Sljivic and G. W. Warr, Period. Biol. (Zagreb),75, 231 (1973).Google Scholar
  14. 14.
    S. H. Snyder, New Engl. J. Med.,296, 266 (1977).Google Scholar
  15. 15.
    S. H. Snyder, S. Matthysse, H. Akil, et al., Neurosci. Res. Program Bull.13 1 (1975).Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • I. N. Maiskii
  • G. P. Airapet'yan
  • A. I. Maiskii
  • R. B. Gudkova
  • É. G. Skryabina
  • T. A. Agafonova
  • S. A. Skhodova
  • Yu. I. Chekanova

There are no affiliations available

Personalised recommendations