Abstract
Acute experiments on rats showed that intragastric injection of an aqueous solution of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) depresses electrical activity of the stomach wall, as reflected in a decrease in the amplitude and frequency of the basic electrical rhythm and, in most cases, its total disappearance. After administration of MNNG the excitatory response of electrical activity both to electrical stimulation of the vagus nerve and to injection of carbachol disappears, but the inhibitory response both to stimulation of the vagus nerve and to injection of ATP is maintained.
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Balitskii, K.P., Syromyatnikov, A.V. Effect of a carcinogen on electrical activity of the rat stomach. Bull Exp Biol Med 88, 1169–1172 (1979). https://doi.org/10.1007/BF00838197
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DOI: https://doi.org/10.1007/BF00838197