Abstract
During aging of an ascites hepatoma 22A (AH22A) the number of cells with fragmented nuclei (especially multilobate) increases: in an AH22A aged 6 days they numbered 15±9.3‱, in a tumor aged 14 days 196±53‰, and in a delayed tumor aged 18 days 453±51‰. The main method of formation of fragmented nuclei is by amitosis. Approximately 150 and 170‰ of cells with fragmented nuclei in a 14- and 18-day old AH22A were in the reversible resting R1 stage (or in a very protracted G1-period, extending over 4 days), whereas the remaining 50 and 230‰ of cells respectively had left the mitotic cycle irreversibly and were evidently undergoing involution, which takes place more rapidly during passage-stimulated division.
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Literature Cited
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Ivleva, T.S., Belyaeva, I.D. Cells with fragmented nuclei in ascites hepatoma 22A and their role in proliferation. Bull Exp Biol Med 88, 1166–1168 (1979). https://doi.org/10.1007/BF00838196
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DOI: https://doi.org/10.1007/BF00838196