Abstract
Mice were immunized with Vi-antigen. Suspensions of spleen cells, removed at various times after immunization, were incubated in Eagle's medium in the presence of14C-glycine. Synthesis of antibodies against Vi-antigen, autoantibodies against mouse IgG, and antigen-dependent nonspecific immunoglobulins (NIg) were determined by the use of specific immunosorbents. Immunization with Vi-antigen sharply intensified in the synthesis of antigen-dependent NIg. The formation of the proteins is thus observed not only during immunization with thymus-dependent antigens, but also in response to thymus-independent antigen. The synthesized antigen-dependent NIg were not autoantibodies against endogenous IgG.
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Sidorova, E.V. Nature and mechanism of synthesis of nonspecific immunoglobulins. Bull Exp Biol Med 88, 1156–1158 (1979). https://doi.org/10.1007/BF00838193
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DOI: https://doi.org/10.1007/BF00838193