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Differences in kinetics of formation of killers and producers of macrophage migration inhibition factor in the primary and secondary response in mixed lymphocyte cultures

  • Microbiology and Immunology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The conditions of killer formation during the primary and secondary response were established in a one-way mixed lymphocyte culture (MLC), stimulated by irradiated or killed allogeneic lymphocytes. Migration inhibition factor (MIF) was found in the culture medium of the MLC as a pointed peak on the 2nd or 3rd day of the primary response and as a plateau after the 1st day of the secondary response, whereas killers were formed much later, reaching a maximum on the 5th and 4th days of culture respectively. The use of heated allogeneic lymphocytes instead of irradiated lymphocytes to stimulate the response in MLC had no effect on the kinetics of the MIF producers but delayed killer formation in the primary MLC.

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Authors
  1. B. D. Brondz
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  2. A. P. Suslov
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  3. A. V. Chervonskii
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  4. A. A. Pimenov
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Brondz, B.D., Suslov, A.P., Chervonskii, A.V. et al. Differences in kinetics of formation of killers and producers of macrophage migration inhibition factor in the primary and secondary response in mixed lymphocyte cultures. Bull Exp Biol Med 88, 1144–1147 (1979). https://doi.org/10.1007/BF00838189

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  • DOI: https://doi.org/10.1007/BF00838189

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