Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 4, pp 1138–1140 | Cite as

Effect of noradrenalin on endogenous prostaglandin E and F2α production in cerebral and extracranial vessels of cats

  • É. A. Amroyan
  • É. S. Gabrielyan
Pharmacology
  • 11 Downloads

Abstract

The production of prostaglandins (PG) E and F in the isolated cerebral and extracranial vessels of cats was determined quantitatively. Basal PG production was found to be greater in the cerebral vessels, and PGF exceeded PGE. On incubation of isolated vessels with noradrenalin, production of vasopressor PGF was reduced, and this was accompanied by a considerable increase in the content of vasopressor PGE. The difference was particularly marked in the cerebral vessels. The level of endogenous PG production by the cerebral vessels, it can tentatively be suggested, has an important role for the local regulation of vascular tone, and a disturbance of their dynamic ratio may be one cause of the development of cerebrovascular pathology.

Key Words

prostaglandins cerebral vessels noradrenalin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    Z. A. Suslina, Zh. Nevropatol. Psikhiat., No. 11, 1635 (1978).Google Scholar
  2. 2.
    R. A. Elliott and H. H. Jasper, J. Neurosurg.,6, 140 (1949).Google Scholar
  3. 3.
    E. S. Gabrielian (É. S. Gabrielyan) and E. A. Amroyan, Acta Physiol. Pharmacol. Bulg.,2, 3 (1976).Google Scholar
  4. 4.
    N. Gilmore, J. R. Vane, and J. H. Wyllie, Nature,218, 1135 (1968).Google Scholar
  5. 5.
    P. Hedquist, Eur. J. Pharmacol.,17, 157 (1972).Google Scholar
  6. 6.
    G. A. Higgs and J. R. Vane, Prostaglandins,4, 695 (1973).Google Scholar
  7. 7.
    P. J. Kadowitz, W. J. George, P. D. Joiner, et al., Adv. Biosci.,9, 501 (1973).Google Scholar
  8. 8.
    S. C. Lee, S. S. Pong, D. Katzen, et al., Biochemistry (Washington),14, 142 (1975).Google Scholar
  9. 9.
    K. U. Malik and J. C. McGiff, Prostaglandins. Physiological, Pharmacological, and Pathological Aspects, Baltimore (1976), p. 103.Google Scholar
  10. 10.
    M. Pennink, R. P. White, J. K. Crockarell, et al., J. Neurosurg.,37, 398 (1972).Google Scholar
  11. 11.
    J. D. Pickard, P. E. Vinall, and F. A. Simeone, Surg. Forum,26, 496 (1975).Google Scholar
  12. 12.
    J. D. Pickard, L. A. MacDonell, E. T. MacKenzie, et al., Eur. J. Pharmacol.,43, 343 (1977).Google Scholar
  13. 13.
    W. G. Unger, J. F. Stamford, and A. Bennett, Nature,233, 336 (1971).Google Scholar
  14. 14.
    L. S. Wolfe, K. Rostworowski, and H. M. Pappius, Can. J. Biochem.,54, 629 (1976).Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • É. A. Amroyan
  • É. S. Gabrielyan

There are no affiliations available

Personalised recommendations