Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 4, pp 1135–1137 | Cite as

Effects of antihistamines on the action of bradykinin

  • G. Ya. Shvarts
Pharmacology

Abstract

Antihistamines, namely Dimedrol (diphenhydramine), Diprazin (Pipolphen), Tavegyl, and Suprastin, reduced the spasmogenic effects of bradykinin and the increased permeability of the microvessels caused by this polypeptide, in isolated segments of guinea pig ileum and also in rats and guinea pigs. The antibradykinin action of the antihistamines is nonspecific in character. No correlation was found between the chemical structure and intensity of the antibradykinin action of the various histamines tested.

Key Words

antihistamines bradykinin smooth muscle microvessels 

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Literature Cited

  1. 1.
    A. D. Ado, General Allergology [in Russian], Moscow (1978).Google Scholar
  2. 2.
    P. Ya. Gaponyuk and V. I. Oivin, Farmakol. Toksikol., No. 3, 321 (1967).Google Scholar
  3. 3.
    P. Ya. Gaponyuk and L. I. Uklonskaya, Farmakol. Toksikol., No. 5, 567 (1970).Google Scholar
  4. 4.
    O. A. Gomazkov and M. V. Shimkovich, Byull. Éksp. Biol. Med., No. 7, 6 (1975).Google Scholar
  5. 5.
    T. S. Pashkina, in: Chemical Factors in the Regulation of Enzyme Activity and Biosynthesis [in Russian], Moscow (1969), pp. 317–359.Google Scholar
  6. 6.
    G. Ya. Shvarts and M. D. Mashkovskii, Farmakol. Toksikol., No. 2, 176 (1976).Google Scholar
  7. 7.
    W. Bernauer et al., Arch. Int. Pharmacodyn.,178, 137 (1969).Google Scholar
  8. 8.
    R. O. Bunag and E. J. Walaszek, J. Pharmacol. Exp. Ther.,136, 254 (1962).Google Scholar
  9. 9.
    I. H. Fleisch and S. I. Ehrenpreis, J. Pharmacol. Exp. Ther.,163, 362 (1968).Google Scholar
  10. 10.
    N. I. Gilmore, Ann. Allergy,37, 420 (1976).Google Scholar
  11. 11.
    H. Konzett and K. Rossler, Arch. Exp. Path. Pharmak.,195, 71 (1940).Google Scholar
  12. 12.
    B. Radmanovic, Jugoslav. Physiol. Pharmacol. Acta,4, Suppl. 1, 211 (1968).Google Scholar
  13. 13.
    C. A. Stone et al., J. Pharmacol. Exp. Ther.,131, 73 (1961).Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • G. Ya. Shvarts

There are no affiliations available

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