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Antiarrhythmic action of tetrodotoxin in the late stage of experimental myocardial infarction

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The action of tetrodotoxin (TT), which blocks the fast inward sodium current, on arrhythmias developing 24 h after occlusion of the coronary artery in ten dogs was studied. After intravenous injection of TT in a dose of 0.5–3.0 μg/kg body weight the number of ventricular extrasystoles was significantly reduced, and in four animals the sinus rhythm was completely restored. The maximal antiarrhythmic effect occurred 3–5 min after injection. It is suggested that the development of arrhythmias and the antiarrhythmic action of drugs in the late stage of myocardial infarction are connected with the fast inward sodium current.

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Authors
  1. L. V. Rozenshtraukh
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  2. E. P. Anyukhovskii
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  3. G. G. Beloshapko
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  4. S. A. Dremin
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Rozenshtraukh, L.V., Anyukhovskii, E.P., Beloshapko, G.G. et al. Antiarrhythmic action of tetrodotoxin in the late stage of experimental myocardial infarction. Bull Exp Biol Med 88, 1114–1116 (1979). https://doi.org/10.1007/BF00838179

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  • DOI: https://doi.org/10.1007/BF00838179

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