Intensity of RNA and protein synthesis in fibroblasts during wound healing in mice
- 17 Downloads
RNA and protein synthesis in fibroblasts was studied by a double-labeling method on the 3rd and 7th days of wound healing in mice by electronmicroscopic autoradiography. The ratio of protein synthesis in the cytoplasm and RNA synthesis in the nucleus was shown to differ significantly in individual cells, with the result that fibroblasts with relative predominance of one of the two types of synthesis were found at both stages of wound healing. On average fibroblasts showed a higher level of protein synthesis on the 3rd day of healing. This high mean level was maintained by an increase in the proportion of fibroblasts in which protein synthesis predominated over RNA synthesis.
Key wordsfibroblast RNA synthesis protein synthesis electronmicroscopic autoradiography wound healing
Unable to display preview. Download preview PDF.
- 1.M. K. Vasil'tsov and A. I. Radostina, Arkh. Anat., No. 2, 80 (1977).Google Scholar
- 2.G. G. Kruglikov and L. L. Shimkevich, in: Connective Tissue in Health and Disease [in Russian], Novosibirsk (1968), p. 162.Google Scholar
- 3.A. A. Makismov, Principles of Histology [in Russian], Part 2, Petrograd (1918), p. 624.Google Scholar
- 4.D. S. Sarkisov, A. A. Pal'tsyn, and B. V. Vtyurin, Adaptive Modifications of Biorhythms [in Russian], Moscow (1975).Google Scholar
- 5.V. N. Smirnov, V. I. Mazurov, V. P. Goncharova, et al., Vopr. Med. Khim., No. 3, 305 (1964).Google Scholar
- 6.A. A. Pal'tsyn and E. G. Kolokol'chikova, Byull. Éksp. Biol. Med., No. 11, 626 (1978).Google Scholar
- 7.E. Kulonen, in: Biology of Fibroblasts, London (1973), p. 3.Google Scholar
- 8.R. Ross, Biol. Rev.,43, 51 (1968).Google Scholar