Abstract
Liberation of histamine from isolated rat mast cells induced by Ketotifen was shown to be inhibited when the ATP reserves in the mast cells are exhausted. Histamine release induced by Ketotifen is a temperature-dependent process and is blocked at a low temperature. It is concluded that Ketotifen is a selective liberator of histamine. The time course of histamine liberation induced by Ketotifen corresponds to partial return of the liberated histamine into the cell.
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Literature Cited
I. S. Gushchin, Patol. Fiziol., No. 1, 32 (1977).
I. S. Gushchin, I. L. Deryugin, and M. E. Kaminka, Byull. Éksp. Biol. Med., No. 3, 329 (1978).
I. S. Gushchin, B. Fredholm, and B. Uvnas, Patol. Fiziol., No. 6, 3 (1975).
B. Diamant, Internat. Arch. Allergy,49, 155 (1975).
B. Fredholm, I. S. Gushchin, K. Elwin, et al., Biochem. Pharmacol.,25, 1583 (1976).
U. Martin and D. Roemer, Monogr. Allergy,12, 145 (1977).
U. Martin and D. Roemer, Allergol. Immunopathol. (Madrid),5, 461 (1977).
F. Muhar and G. Csajkas, Allergol. Immunopathol.,5, 460 (1977).
C. Peterson, Acta Physiol. Scand., Suppl. 413, 1 (1974).
B. Wüthrich, P. Radielovic, and M. Debelic, Allergol. Immunopathol. (Madrid),5, 461 (1977).
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Gushchin, I.S., Deryugin, I.L. Ketotifen, a selective histamine releaser. Bull Exp Biol Med 88, 1342–1344 (1979). https://doi.org/10.1007/BF00835592
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DOI: https://doi.org/10.1007/BF00835592