Abstract
Partial splenectomy was performed on (CBA x C57BL/6)F1 hybrid mice 2, 12, 15, and 20 days before induction of the graft versus host reaction (GVHR) and 2 and 10 days after injection of parental immunocompetent cells. Recipients with an intact spleen, and those undergoing total splenectomy or a mock operation served as the control. Hybrids with a regenerating spleen up to 12 days of regeneration were shown to have increased resistance to GVHR, whereas splenectomy increased the resistance of the hybrids to GVHR only if carried out 2 days before induction of GVHR or 2 days after it.
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Meshkova, R.Y. Increased resistance of (CBA x C57BL/6)F1 hybrids to the systemic graft versus host reaction during regeneration of the spleen. Bull Exp Biol Med 88, 1330–1332 (1979). https://doi.org/10.1007/BF00835588
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DOI: https://doi.org/10.1007/BF00835588