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Regional redistribution of blood at the climax and during decline of the febrile response in rats

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Fever was induced by intravenous injection of rabbit leukocytic pyrogen and also by intravenous injection of pyrogenal. Leukocytic pyrogen led to a greater rise of temperature. In all series of experiments multivariate statistical analysis revealed the predominant influence of two factors. One reflected responses leading to a relative reduction in blood volume in the brain, myocardium, lungs, and liver and to its increase in some abdominal organs, the skin, muscular and bony tissues of the limbs, abdomen, and pelvis. The other factor reflected influences aimed at the redistribution of blood chiefly from the organs and tissues of the head, neck, and thorax into the liver.

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Authors
  1. O. A. Kovalev
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  2. A. V. Sorokin
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  3. M. A. Batyaev
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  4. V. I. Severovostokova
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  5. S. K. Sheremetevskaya
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Kovalev, O.A., Sorokin, A.V., Batyaev, M.A. et al. Regional redistribution of blood at the climax and during decline of the febrile response in rats. Bull Exp Biol Med 88, 1258–1261 (1979). https://doi.org/10.1007/BF00835565

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  • DOI: https://doi.org/10.1007/BF00835565

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