Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 5, pp 1248–1251 | Cite as

Prostaglandins, cyclic nucleotides, and adaptation of the heart to acute and chronic pressure overloading

  • N. G. Geling
  • V. D. Pomoinetskii
  • V. M. Samfirova
Pathological Physiology and General Pathology


The concentration of prostaglandins (PG) and cyclic nucleotides was determined in the rat heart at different times after coarctation of the abdominal aorta. The animals were divided into three types depending on the rate of development and degree of hypertrophy. Rats best adapted to pressure overloading of the heart (with the greatest degree of hypertrophy) had the highest PG level in the myocardium. Correlation was found between the increase in weight of the heart and the PGE/PGF ratio. A connection was demonstrated between PG and cyclic nucleotides in the myocardium in the course of its adaptation to pressure overloading. It is suggested that PG may be an important component of the system of adaptation of the heart to pressure overloading.

Key words

Pressure overloading of the heart adaptation prostaglandins cyclic nucleotides 


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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • N. G. Geling
  • V. D. Pomoinetskii
  • V. M. Samfirova

There are no affiliations available

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